Neurodegenerative diseases, a subset of age-driven diseases, have been known to exhibit
increased oxidative stress. The resultant increase in reactive oxygen species (ROS) has …

Hydroethidine (HE; or dihydroethidium) is the most popular fluorogenic probe used for
detecting intracellular superoxide radical anion. The reaction between superoxide and HE …

Failure to secrete adequate amounts of insulin in response to increasing concentrations of
glucose is an important feature of type 2 diabetes. The mechanism for loss of glucose …

Recent evidence indicates that oxidative stress is central to the pathogenesis of a wide
variety of degenerative diseases, aging, and cancer. Oxidative stress occurs when the …

Plant mitochondria produce reactive oxygen species (ROS) as an unavoidable side product
of aerobic metabolism, but they have mechanisms for regulating this production such as the …

The Helicobacter pylori vacuolating cytotoxin (VacA) intoxicates mammalian cells resulting
in reduction of mitochondrial transmembrane potential (ΔΨm reduction) and cytochrome c …

Proline oxidase (POX), often considered a 'housekeeping enzyme'might play an important
role in apoptosis. We have shown that POX generated proline-dependent reactive oxygen …

Background and Purpose Oxaliplatin is a platinum‐based chemotherapeutic drug used as a
first‐line therapy for colorectal cancer. However, its use is associated with severe …

We examined the temporal and causal relationship between Smac/DIABLO release,
cytochrome c (cyt-c) release, and caspase activation at the single cell level during apoptosis …

Commercially available lipid emulsions for parenteral nutrition are mainly composed by long
chain triacylglycerol containing a high proportion of linoleic acid (LA) or oleic acid (OA). The …