CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats-associated protein
9) shows the opportunity to treat a diverse array of untreated various genetic and …

Heritable cardiomyopathies are a class of heart diseases caused by variations in a number
of genetic loci. Genetic variants on one allele lead to either a degraded protein, which …

The extraordinary wave of genomic-engineering innovation, driven by CRISPR-Cas9, has
sparked worldwide scientific and ethical uncertainty. Great concern has arisen across the …

Applications of CRISPR in human health and in gene drives are at the forefront of biological
research as tools. This technology will affect humankind and our environment, so as this …

Targeted modifications of the human epigenome, epigenome editing (EE), are around the
corner. For EE, techniques similar to genome editing (GE) techniques are used. While in GE …

Although the potential advantages of clinical germline genome editing (GGE) over currently
available methods are limited, the implementation of GGE in the clinic has been proposed …

Technological developments in gene editing raise high expectations for clinical applications,
including editing of the germline. The European Society of Human Reproduction and …

Human history is inextricably linked to the introduction of desirable heritable traits in plants
and animals. Selective breeding (SB) predates our historical period and has been practiced …

Purpose Genome editing holds both tremendous therapeutic promise and significant
potential risk. Sickle cell disease (SCD), the most commonly inherited blood disorder, is a …

This paper presents the results of a qualitative study based on semi-structured interviews of
10 expert patient advocates on several different issues around Advanced Therapy Medicinal …