Validation of the γH2AX biomarker for genotoxicity assessment: a review
B Kopp, L Khoury, M Audebert - Archives of toxicology, 2019 - Springer
The H2AX histone protein is rapidly phosphorylated at the serine-139 position (γH2AX) in
response to a broad range of DNA lesions. γH2AX induction is one of the earliest events in …
response to a broad range of DNA lesions. γH2AX induction is one of the earliest events in …
The in vitro MN assay in 2011: origin and fate, biological significance, protocols, high throughput methodologies and toxicological relevance
M Kirsch-Volders, G Plas, A Elhajouji… - Archives of …, 2011 - Springer
Micronuclei (MN) are small, extranuclear bodies that arise in dividing cells from acentric
chromosome/chromatid fragments or whole chromosomes/chromatids lagging behind in …
chromosome/chromatid fragments or whole chromosomes/chromatids lagging behind in …
Guidance on risk assessment of nanomaterials to be applied in the food and feed chain: Human and animal health
EFSA Scientific Committee, S More, V Bampidis… - Efsa …, 2021 - Wiley Online Library
The EFSA has updated the Guidance on risk assessment of the application of nanoscience
and nanotechnologies in the food and feed chain, human and animal health. It covers the …
and nanotechnologies in the food and feed chain, human and animal health. It covers the …
Guidance on risk assessment of nanomaterials to be applied in the food and feed chain: human and animal health
EFSA Scientific Committee - EFSA Journal, 2021 - orbit.dtu.dk
The EFSA has updated the Guidance on risk assessment of the application of nanoscience
and nanotechnologies in the food and feed chain, human and animal health. It covers the …
and nanotechnologies in the food and feed chain, human and animal health. It covers the …
Two aldehyde clearance systems are essential to prevent lethal formaldehyde accumulation in mice and humans
Reactive aldehydes arise as by-products of metabolism and are normally cleared by
multiple families of enzymes. We find that mice lacking two aldehyde detoxifying enzymes …
multiple families of enzymes. We find that mice lacking two aldehyde detoxifying enzymes …
Cytotoxicity and genotoxicity of nano-and microparticulate copper oxide: role of solubility and intracellular bioavailability
A Semisch, J Ohle, B Witt, A Hartwig - Particle and fibre toxicology, 2014 - Springer
Background Nano-or microscale copper oxide particles (CuO NP, CuO MP) are increasingly
applied as catalysts or antimicrobial additives. This increases the risk of adverse health …
applied as catalysts or antimicrobial additives. This increases the risk of adverse health …
[图书][B] Handbook of toxicology
MJ Derelanko, MA Hollinger - 2001 - api.taylorfrancis.com
LOCATE FREQUENTLY USED INFORMATION EASILY AND QUICKLYWorking in the
laboratory or office, you use a diverse assortment of basic information to design, conduct …
laboratory or office, you use a diverse assortment of basic information to design, conduct …
High throughput toxicity screening and intracellular detection of nanomaterials
With the growing numbers of nanomaterials (NMs), there is a great demand for rapid and
reliable ways of testing NM safety—preferably using in vitro approaches, to avoid the ethical …
reliable ways of testing NM safety—preferably using in vitro approaches, to avoid the ethical …
Genotoxicity of silver nanoparticles evaluated using the Ames test and in vitro micronucleus assay
Y Li, DH Chen, J Yan, Y Chen, RA Mittelstaedt… - … /Genetic Toxicology and …, 2012 - Elsevier
Silver nanoparticles (AgNPs) have antimicrobial properties, which have contributed to their
widespread use in consumer products. A current issue regarding nanomaterials is the extent …
widespread use in consumer products. A current issue regarding nanomaterials is the extent …
Genotoxicity of TiO2 nanoparticles assessed by mini-gel comet assay and micronucleus scoring with flow cytometry
S Di Bucchianico, F Cappellini, F Le Bihanic… - …, 2017 - academic.oup.com
The widespread production and use of nanoparticles calls for faster and more reliable
methods to assess their safety. The main aim of this study was to investigate the genotoxicity …
methods to assess their safety. The main aim of this study was to investigate the genotoxicity …