The incidence of antibiotic resistance within and beyond the agricultural ecosystem: A concern for public health
The agricultural ecosystem creates a platform for the development and dissemination of
antimicrobial resistance, which is promoted by the indiscriminate use of antibiotics in the …
antimicrobial resistance, which is promoted by the indiscriminate use of antibiotics in the …
Evolutionary pathways and trajectories in antibiotic resistance
Evolution is the hallmark of life. Descriptions of the evolution of microorganisms have
provided a wealth of information, but knowledge regarding “what happened” has precluded …
provided a wealth of information, but knowledge regarding “what happened” has precluded …
Experimental design, population dynamics, and diversity in microbial experimental evolution
In experimental evolution, laboratory-controlled conditions select for the adaptation of
species, which can be monitored in real time. Despite the current popularity of such …
species, which can be monitored in real time. Despite the current popularity of such …
Biased partitioning of the multidrug efflux pump AcrAB-TolC underlies long-lived phenotypic heterogeneity
The molecular mechanisms underlying phenotypic variation in isogenic bacterial
populations remain poorly understood. We report that AcrAB-TolC, the main multidrug efflux …
populations remain poorly understood. We report that AcrAB-TolC, the main multidrug efflux …
How antibiotics work together: molecular mechanisms behind combination therapy
GJ Sullivan, NN Delgado, R Maharjan… - Current opinion in …, 2020 - Elsevier
Highlights•Combination therapy is an important tool for tackling antibiotic resistance.•In
depth molecular studies for combination therapy are lacking.•We summarise six major …
depth molecular studies for combination therapy are lacking.•We summarise six major …
Escherichia coli β-Lactamases: What Really Matters
Escherichia coli strains belonging to diverse pathotypes have increasingly been recognized
as a major public health concern. The β-lactam antibiotics have been used successfully to …
as a major public health concern. The β-lactam antibiotics have been used successfully to …
Bottleneck size and selection level reproducibly impact evolution of antibiotic resistance
N Mahrt, A Tietze, S Künzel, S Franzenburg… - Nature Ecology & …, 2021 - nature.com
During antibiotic treatment, the evolution of bacterial pathogens is fundamentally affected by
bottlenecks and varying selection levels imposed by the drugs. Bottlenecks—that is …
bottlenecks and varying selection levels imposed by the drugs. Bottlenecks—that is …
Evolutionary approaches to combat antibiotic resistance: opportunities and challenges for precision medicine
M Merker, L Tueffers, M Vallier, EE Groth… - Frontiers in …, 2020 - frontiersin.org
The rise of antimicrobial resistance (AMR) in bacterial pathogens is acknowledged by the
WHO as a major global health crisis. It is estimated that in 2050 annually up to 10 million …
WHO as a major global health crisis. It is estimated that in 2050 annually up to 10 million …
Plasmid-mediated phenotypic noise leads to transient antibiotic resistance in bacteria
JCR Hernandez-Beltran, J Rodríguez-Beltrán… - Nature …, 2024 - nature.com
The rise of antibiotic resistance is a critical public health concern, requiring an
understanding of mechanisms that enable bacteria to tolerate antimicrobial agents. Bacteria …
understanding of mechanisms that enable bacteria to tolerate antimicrobial agents. Bacteria …
Seeking patterns of antibiotic resistance in ATLAS, an open, raw MIC database with patient metadata
Antibiotic resistance represents a growing medical concern where raw, clinical datasets are
under-exploited as a means to track the scale of the problem. We therefore sought patterns …
under-exploited as a means to track the scale of the problem. We therefore sought patterns …