Background: Limited accessibility of drugs to the tumor tissues, the requirement of high
doses, intolerable cytotoxicity, the development of multiple drug resistance and non-specific …

Adeno-associated virus (AAV) is one of the most promising viral gene transfer vectors that
has been shown to effect long-term gene expression and disease correction with low toxicity …

Vectors based on adeno-associated virus serotype 2 (AAV2) have been used extensively in
many gene-delivery applications, including several successful clinical trials for one type of …

Bioprinting is a novel technology that may help to overcome limitations associated with two-
dimensional (2D) cell cultures and animal experiments, as it allows the production of three …

Nano-engineered particles have been developed to reach specific molecular targets on
diseased cells and have been used in various experimental and clinical conditions. The …

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) selectively kills tumor cells.
However, its short half-life, poor delivery, and TRAIL-resistant tumor cells have diminished …

Solute carriers (SLCs) are essential for brain physiology and homeostasis due to their role in
transporting necessary substances across cell membranes. There is an increasing need to …

Glioblastoma multiforme (GBM) is a serious form of brain cancer for which there is currently
no effective treatment. Alternative strategies such as adeno-associated virus (AAV) vector …

SLC11A1 is known to link infections, autoimmunity and cancers. A review is presented of the
mechanisms by which a balance is maintained between infections caused by pathogens …

Glioblastoma multiforme (GBM) is a devastating form of brain cancer for which there is no
effective treatment. Here, we report a novel approach to brain tumor therapy through genetic …