The skeletal muscle is the largest organ in the body and secretes circulating factors,
including myokines, which are involved in various cellular signaling processes. Skeletal …

Maintaining proper energy balance in mammals entails intimate crosstalk between various
tissues and organs. These inter-organ communications are mediated, to a great extent, by …

Background There is currently an unmet clinical need to develop better pharmacological
treatments to improve glucose handling in Type II Diabetes patients with obesity. To this end …

Aims/hypothesis Oxidative stress, inflammation and cell death are closely involved in the
development of diabetic cardiomyopathy (DCM). C1q/tumour necrosis factor-related protein …

As the largest endocrine organ, adipose tissue secretes many bioactive molecules that
circulate in blood, collectively termed adipokines. Efforts to identify such metabolic …

Obesity is associated with chronic low-grade inflammation, and metabolic regulators linking
obesity to inflammation have therefore received much attention. Secreted C1q/TNF-related …

CTRP9 is a secreted multimeric protein of the C1q family and the closest paralog of the
insulin-sensitizing adipokine, adiponectin. The metabolic function of this adipose tissue …

Cells turn on autophagy, an intracellular recycling pathway, when deprived of nutrients. How
autophagy is regulated by hormonal signals in response to major changes in metabolic state …

Aims C1q-tumour necrosis factor-related protein-3 (CTRP3) is an adipokine and a paralog of
adiponectin. Our previous study showed that CTRP3 attenuated diabetes-related …

Transgenic overexpression of CTRP9, a secreted hormone downregulated in obesity,
confers striking protection against diet-induced obesity and type 2 diabetes. However, the …