Endothelial dysfunction in atherosclerotic cardiovascular diseases and beyond: from mechanism to pharmacotherapies
The endothelium, a cellular monolayer lining the blood vessel wall, plays a critical role in
maintaining multiorgan health and homeostasis. Endothelial functions in health include …
maintaining multiorgan health and homeostasis. Endothelial functions in health include …
MCP-1: Function, regulation, and involvement in disease
S Singh, D Anshita, V Ravichandiran - International immunopharmacology, 2021 - Elsevier
Abstract MCP-1 (Monocyte chemoattractant protein-1), also known as Chemokine (CC-motif)
ligand 2 (CCL2), is from family of CC chemokines. It has a vital role in the process of …
ligand 2 (CCL2), is from family of CC chemokines. It has a vital role in the process of …
[HTML][HTML] Efficacy and safety of baricitinib for the treatment of hospitalised adults with COVID-19 (COV-BARRIER): a randomised, double-blind, parallel-group, placebo …
Background Baricitinib is an oral selective Janus kinase 1/2 inhibitor with known anti-
inflammatory properties. This study evaluates the efficacy and safety of baricitinib in …
inflammatory properties. This study evaluates the efficacy and safety of baricitinib in …
Efficacy and safety of baricitinib plus standard of care for the treatment of critically ill hospitalised adults with COVID-19 on invasive mechanical ventilation or …
EW Ely, AV Ramanan, CE Kartman… - The Lancet …, 2022 - thelancet.com
Summary Background The oral, selective Janus kinase 1/2 inhibitor baricitinib has shown
efficacy in studies of hospitalised adults with COVID-19. COV-BARRIER (NCT04421027) …
efficacy in studies of hospitalised adults with COVID-19. COV-BARRIER (NCT04421027) …
SARS-CoV-2 infection drives an inflammatory response in human adipose tissue through infection of adipocytes and macrophages
GJ Martínez-Colón, K Ratnasiri, H Chen… - Science Translational …, 2022 - science.org
Obesity, characterized by chronic low-grade inflammation of the adipose tissue, is
associated with adverse coronavirus disease 2019 (COVID-19) outcomes, yet the …
associated with adverse coronavirus disease 2019 (COVID-19) outcomes, yet the …
SARS-CoV-2 neutralizing antibody LY-CoV555 in outpatients with Covid-19
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes
coronavirus disease 2019 (Covid-19), which is most frequently mild yet can be severe and …
coronavirus disease 2019 (Covid-19), which is most frequently mild yet can be severe and …
Baricitinib plus remdesivir for hospitalized adults with Covid-19
Abstract Background Severe coronavirus disease 2019 (Covid-19) is associated with
dysregulated inflammation. The effects of combination treatment with baricitinib, a Janus …
dysregulated inflammation. The effects of combination treatment with baricitinib, a Janus …
T cell apoptosis characterizes severe Covid-19 disease
S André, M Picard, R Cezar, F Roux-Dalvai… - Cell Death & …, 2022 - nature.com
Severe SARS-CoV-2 infections are characterized by lymphopenia, but the mechanisms
involved are still elusive. Based on our knowledge of HIV pathophysiology, we hypothesized …
involved are still elusive. Based on our knowledge of HIV pathophysiology, we hypothesized …
COVCOG 2: cognitive and memory deficits in long COVID: a second publication from the COVID and cognition study
COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has
been often characterized as a respiratory disease. However, it is increasingly being …
been often characterized as a respiratory disease. However, it is increasingly being …
Alterations in microbiota of patients with COVID-19: potential mechanisms and therapeutic interventions
The global coronavirus disease 2019 (COVID-19) pandemic is currently ongoing. It is
caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A high …
caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A high …