[HTML][HTML] Translocator protein (18 kDa)(TSPO) as a therapeutic target for neurological and psychiatric disorders
R Rupprecht, V Papadopoulos, G Rammes… - Nature reviews Drug …, 2010 - nature.com
Abstract The translocator protein (18 kDa)(TSPO) is localized primarily in the outer
mitochondrial membrane of steroid-synthesizing cells, including those in the central and …
mitochondrial membrane of steroid-synthesizing cells, including those in the central and …
The 18 kDa translocator protein, microglia and neuroinflammation
GJ Liu, RJ Middleton, CR Hatty, WWY Kam… - Brain …, 2014 - Wiley Online Library
The 18 kDa translocator protein (TSPO), previously known as the peripheral
benzodiazepine receptor, is expressed in the injured brain. It has become known as an …
benzodiazepine receptor, is expressed in the injured brain. It has become known as an …
An 18-kDa translocator protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28
[11C] PBR28 binds the 18-kDa Translocator Protein (TSPO) and is used in positron
emission tomography (PET) to detect microglial activation. However, quantitative …
emission tomography (PET) to detect microglial activation. However, quantitative …
Cholesterol transport in steroid biosynthesis: Role of protein–protein interactions and implications in disease states
MB Rone, J Fan, V Papadopoulos - … Acta (BBA)-Molecular and Cell Biology …, 2009 - Elsevier
The transfer of cholesterol from the outer to the inner mitochondrial membrane is the rate-
limiting step in hormone-induced steroid formation. To ensure that this step is achieved …
limiting step in hormone-induced steroid formation. To ensure that this step is achieved …
Perturbations of native membrane protein structure in alkyl phosphocholine detergents: a critical assessment of NMR and biophysical studies
Membrane proteins perform a host of vital cellular functions. Deciphering the molecular
mechanisms whereby they fulfill these functions requires detailed biophysical and structural …
mechanisms whereby they fulfill these functions requires detailed biophysical and structural …
Peripheral benzodiazepine receptor/translocator protein global knock-out mice are viable with no effects on steroid hormone biosynthesis*♦
LN Tu, K Morohaku, PR Manna, SH Pelton… - Journal of Biological …, 2014 - ASBMB
Translocator protein (TSPO), previously known as the peripheral benzodiazepine receptor,
is a mitochondrial outer membrane protein implicated as essential for cholesterol import to …
is a mitochondrial outer membrane protein implicated as essential for cholesterol import to …
Structure of the mitochondrial translocator protein in complex with a diagnostic ligand
Ł Jaremko, M Jaremko, K Giller, S Becker… - Science, 2014 - science.org
The 18-kilodalton translocator protein TSPO is found in mitochondrial membranes and
mediates the import of cholesterol and porphyrins into mitochondria. In line with the role of …
mediates the import of cholesterol and porphyrins into mitochondria. In line with the role of …
Neurosteroid biosynthesis: enzymatic pathways and neuroendocrine regulation by neurotransmitters and neuropeptides
Neuroactive steroids synthesized in neuronal tissue, referred to as neurosteroids, are
implicated in proliferation, differentiation, activity and survival of nerve cells. Neurosteroids …
implicated in proliferation, differentiation, activity and survival of nerve cells. Neurosteroids …
Role of mitochondria in steroidogenesis
V Papadopoulos, WL Miller - … practice & research Clinical endocrinology & …, 2012 - Elsevier
Adrenal gonadal, placental and brain mitochondria contain several steroidogenic enzymes,
notably the cholesterol side chain cleavage enzyme, P450scc, which is the enzymatic rate …
notably the cholesterol side chain cleavage enzyme, P450scc, which is the enzymatic rate …
In vivo TSPO signal and neuroinflammation in Alzheimer's disease
In the last decade, positron emission tomography (PET) and single-photon emission
computed tomography (SPECT) in in vivo imaging has attempted to demonstrate the …
computed tomography (SPECT) in in vivo imaging has attempted to demonstrate the …