The development of thrombotic disorders in humans is one of the most common causes of
morbidity and mortality in the Western world. Thrombotic disease can be classified in broad …

Collagens are important platelet activators in the vascular subendothelium and vessel wall.
Since the regulation of platelet activation is a key step in distinguishing normal haemostasis …

Type 1 von Willebrand disease (VWD) is characterized by a personal and family history of
bleeding coincident with reduced levels of normal plasma von Willebrand factor (VWF). The …

Summary Background: Closure time (CT), measured by platelet function analyzer (PFA‐
100®) device, is now available to the clinical laboratory as a possible alternative or …

Abbreviations: α2β1-integrin= collagen receptor; ADP= adenosine diphosphate; BT=
bleeding time; CADP= collagen plus adenosine-5-diphosphate; CADP-CT= collagen …

Abstract The platelet glycoproteins (GPs) Ib, integrin α2β1, and GPVI are considered central
to thrombus formation. Recently, their relative importance has been re-evaluated based on …

Aggregometry is widely used to assess platelet function, but its use in identifying platelet
hyperreactivity is poorly defined. We studied platelet aggregation in 359 healthy individuals …

The PFA‐100® provides a simple global measure of high shear‐dependent platelet
function, and as such is not diagnostic or specific to any disorder. Prolonged closure times …

DNA samples collected as part of a large population-based casecontrol study were
genotyped to examine the associations of five prothrombotic gene polymorphisms with pre …

Anti-platelet drug therapy is currently performed without monitoring, because the established
method of platelet aggregometry is cumbersome. The recently developed platelet function …