Integrins are a family of transmembrane cell surface molecules that constitute the principal
adhesion receptors for the extracellular matrix (ECM) and are indispensable for the …

The formation of epithelial cell barriers results from the defined spatiotemporal differentiation
of stem cells into a specialized and polarized epithelium, a process termed mesenchymal …

Difficulties in the detection, diagnosis, and treatment of ovarian cancer result in an overall
low survival rate of women with this disease. A better understanding of the pathways …

Introduction: The advent of high throughput technologies capable of comprehensive
analysis of genes, transcripts, proteins and other significant biological molecules has …

Epithelial-mesenchymal transition (EMT) is an essential process that drives polarized,
immotile mammary epithelial cells (MECs) to acquire apolar, highly migratory fibroblastoid …

Here, we identify a mouse homolog of the Drosophila Disabled (Dab) protein, mDab1, and
show it is an adaptor molecule functioning in neural development. We find that mDab1 is …

Disabled gene products are important for nervous system development in drosophila and
mammals. In mice, the Dab1 protein is thought to function downstream of the extracellular …

Secreted protein acidic and rich in cysteine (SPARC) is an extracellular Ca2+-binding
matricellular glycoprotein that associates with cell populations undergoing migration …

A better understanding of the molecular circuitry in normal ovarian tissues and in ovarian
cancer will likely provide new targets for diagnosis and therapy. Recently, much has been …

Using a genetic complementation approach we have identified disabled‐2 (Dab2), a
structural homolog of the Dab1 adaptor molecule, as a critical link between the transforming …