[HTML][HTML] Recent advancements in optical harmonic generation microscopy: Applications and perspectives

S JamesDarian, J CampagnolaPaul - BME frontiers, 2021 - spj.science.org
Second harmonic generation (SHG) and third harmonic generation (THG) microscopies
have emerged as powerful imaging modalities to examine structural properties of a wide …

Biomaterial considerations for ovarian cancer models

M Kramer, A Criswell, MK Sewell-Loftin - Frontiers in Materials, 2023 - frontiersin.org
Ovarian cancer is the 5th most common and the deadliest gynecological cancer, with a 5-
year survival rate of less than 50 percent. Most deaths due to ovarian cancer are caused by …

PSHG-TISS: A collection of polarization-resolved second harmonic generation microscopy images of fixed tissues

R Hristu, SG Stanciu, A Dumitru, LG Eftimie, B Paun… - Scientific Data, 2022 - nature.com
Second harmonic generation (SHG) microscopy is acknowledged as an established
imaging technique capable to provide information on the collagen architecture in tissues that …

Characterization of pancreatic cancer tissue using multiphoton excitation fluorescence and polarization-sensitive harmonic generation microscopy

D Tokarz, R Cisek, A Joseph, A Golaraei… - Frontiers in …, 2019 - frontiersin.org
Thin tissue sections of normal and tumorous pancreatic tissues stained with hematoxylin
and eosin were investigated using multiphoton excitation fluorescence (MPF), second …

Characterization of pathological thyroid tissue using polarization-sensitive second harmonic generation microscopy

D Tokarz, R Cisek, A Joseph, SL Asa… - Laboratory …, 2020 - nature.com
Polarization-sensitive second harmonic generation (SHG) microscopy is an established
imaging technique able to provide information related to specific molecular structures …

Super‐Multiplex Nonlinear Optical Imaging Unscrambles the Statistical Complexity of Cancer Subtypes and Tumor Microenvironment

Y Li, B Shen, G Zou, R Hu, Y Pan, J Qu… - Advanced …, 2022 - Wiley Online Library
Label‐free nonlinear optical imaging (NLOI) has made tremendous inroads toward
unscrambling the microcosmic complexity of cancers. However, harmonic and Raman …

Probing ECM remodeling in idiopathic pulmonary fibrosis via second harmonic generation microscopy analysis of macro/supramolecular collagen structure

DS James, AN Jambor, HY Chang… - … of biomedical optics, 2020 - spiedigitallibrary.org
Idiopathic pulmonary fibrosis (IPF) is a progressive disease with poor prognosis with short
lifespan following diagnosis as patients have limited effective treatment options. A …

Evaluation of a polarization-enhanced laparoscopy prototype for improved intra-operative visualization of peritoneal metastases

T Schnelldorfer, E Gnanatheepam, R Trout, A Gado… - Scientific Reports, 2023 - nature.com
Despite careful staging, the accuracy for preoperative detection of small distant metastases
remains poor, creating a clinical need for enhanced operative staging to detect occult …

Quantification of collagen fiber structure using second harmonic generation imaging and two‐dimensional discrete Fourier transform analysis: application to the …

JK Pijanka, PP Markov, D Midgett… - Journal of …, 2019 - Wiley Online Library
Second harmonic generation (SHG) microscopy is widely used to image collagen fiber
microarchitecture due to its high spatial resolution, optical sectioning capabilities and …

Characterization of pathological stomach tissue using polarization-sensitive second harmonic generation microscopy

H Jeon, MA Harvey, R Cisek, E Bennett… - Biomedical Optics …, 2023 - opg.optica.org
Alterations in collagen ultrastructure between human gastric adenocarcinoma and normal
gastric tissue were investigated using polarization-resolved second harmonic generation …