Short-term patient and graft outcomes continue to improve after kidney and liver
transplantation, with 1-year survival rates over 80%; however, improving longer-term …

The aim of this study was to develop a population pharmacokinetic model of tacrolimus in
pediatric kidney transplant patients, identify factors that explain variability, and determine …

Background. Norovirus infection is the most common cause of acute self-limiting
gastroenteritis. Only 3 cases of chronic norovirus infection in adult solid organ transplant …

Introduction: ATP-binding cassette (ABC) transporters, especially P-glycoprotein (P-gp), and
various metabolic enzymes, in particular, CYP3A, expressed in the small intestine …

In children, the main causes of chronic kidney disease (CKD) are congenital diseases and
glomerular disorders. CKD is associated with multiple physiological changes and may …

Diarrhea is common in transplant recipients. While the majority of cases are mild and
transient, some are severe and prolonged, which can threaten graft survival through …

Tacrolimus, an immunosuppressant used after organ transplantation, has a narrow
therapeutic range and its pharmacokinetic variability complicates its daily dose assessment …

Tacrolimus is a first-line calcineurin inhibitor (CNI) and an integral part of the
immunosuppressive strategy in solid organ transplantation. Being a dose-critical drug …

As tacrolimus has a rather narrow therapeutic range and high individual variability in its
pharmacokinetics, it is important to determine the cause of the variation in tacrolimus …

Background Cryptosporidial enteritis, a diarrheal infection of the small intestine caused by
the apicomplexan protozoa C ryptosporidium, is infrequently recognized in transplant …