Potassium (K+) channels are highly regulated membrane proteins that control the potassium
ion flux and respond to different cellular stimuli. These ion channels are grouped into three …

Potassium (K+) channels play vital roles in various physiological functions, including
regulating K+ flow in cell membranes, impacting nervous system signal transduction …

A new series of dual low nanomolar benzothiazole inhibitors of bacterial DNA gyrase and
topoisomerase IV were developed. The resulting compounds show excellent broad …

New 2-pyrrolamidobenzothiazole-based inhibitors of mycobacterial DNA gyrase were
discovered. Among these, compounds 49 and 51, show excellent antibacterial activity …

Cancer has been an insurmountable problem in the history of medical science. The
uncontrollable proliferation of cancer cells is one of cancer's main characteristics, which is …

Expression of the voltage-gated potassium channel KV10. 1 (Eag1) has been detected in
over 70% of human cancers, making the channel a promising new target for new anticancer …

Abstract Ether-à-go-go (EAG) potassium channels play a crucial role in the regulation of
neuronal excitability and cancer progression, rendering them potential drug targets for …

The KV10. 1 voltage-gated potassium channel is highly expressed in 70% of tumors, and
thus represents a promising target for anticancer drug discovery. However, only a few …

T-type calcium (CaV3) channels are involved in cardiac automaticity, development, and
excitation–contraction coupling in normal cardiac myocytes. Their functional role becomes …

Cardiovascular diseases are the leading cause of death in the world, accounting for the
death of 17.9 million people every year. Based on data from the World Health Organization …