Terpenoids' anti-cancer effects: Focus on autophagy

C El-Baba, A Baassiri, G Kiriako, B Dia, S Fadlallah… - Apoptosis, 2021 - Springer
Terpenoids are the largest class of natural products, most of which are derived from plants.
Amongst their numerous biological properties, their anti-tumor effects are of interest for they …

[HTML][HTML] Anticancer activity of oleanolic acid and its derivatives: Recent advances in evidence, target profiling and mechanisms of action

ZY Tang, Y Li, YT Tang, XD Ma, ZY Tang - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Abstract Oleanolic acid (OA, 3 β-hydroxyoleanolic acid-12-en-28-oic acid) is a pentacyclic
triterpenoid present in many plants. As a new framework for development of semi synthetic …

Oleanolic acid and its synthetic derivatives for the prevention and therapy of cancer: preclinical and clinical evidence

MK Shanmugam, X Dai, AP Kumar, BKH Tan, G Sethi… - Cancer letters, 2014 - Elsevier
Abstract Oleanolic acid (OA, 3β-hydroxyolean-12-en-28-oic acid) is a ubiquitous pentacyclic
multifunctional triterpenoid, widely found in several dietary and medicinal plants. Natural …

Natural product triterpenoids and their semi-synthetic derivatives with potential anticancer activity

Y Ren, AD Kinghorn - Planta Medica, 2019 - thieme-connect.com
Triterpenoids are distributed widely in higher plants and are of interest because of their
structural diversity and broad range of bioactivities. In particular, there is a very large …

Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK–p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis

X Wang, H Bai, X Zhang, J Liu, P Cao, N Liao… - …, 2013 - academic.oup.com
Incidence of hepatocellular carcinoma (HCC) is dramatically increasing and is the third
cause of cancer death worldwide. One key approach to control HCC is chemoprevention by …

Oleanolic acid alters multiple cell signaling pathways: implication in cancer prevention and therapy

L Žiberna, D Šamec, A Mocan, SF Nabavi… - International journal of …, 2017 - mdpi.com
Nowadays, much attention has been paid to diet and dietary supplements as a cost-effective
therapeutic strategy for prevention and treatment of a myriad of chronic and degenerative …

Bioactive properties of the main triterpenes found in olives, virgin olive oil, and leaves of Olea europaea

C Sánchez-Quesada, A López-Biedma… - Journal of agricultural …, 2013 - ACS Publications
Oleanolic acid, maslinic acid, uvaol, and erythrodiol are the main triterpenes present in
olives, olive tree leaves, and virgin olive oil. Their concentration in virgin olive oil depends …

Phytochemistry and pharmacology of plants in the genus Chaenomeles

R Xu, M Kuang, N Li - Archives of Pharmacal Research, 2023 - Springer
Chaenomeles plants belong to the Rosaceae family and include five species, Chaenomeles
speciosa (Sweet) Nakai, Chaenomeles sinensis (Thouin) Koehne, Chaenomeles japonica …

Ursolic acid and related analogues: triterpenoids with broad health benefits

HN Nguyen, SL Ullevig, JD Short, L Wang, YJ Ahn… - Antioxidants, 2021 - mdpi.com
Ursolic acid (UA) is a well-studied natural pentacyclic triterpenoid found in herbs, fruit and a
number of traditional Chinese medicinal plants. UA has a broad range of biological activities …

[HTML][HTML] Clove extract inhibits tumor growth and promotes cell cycle arrest and apoptosis

H Liu, JC Schmitz, J Wei, S Cao, JH Beumer… - Oncology …, 2014 - ncbi.nlm.nih.gov
Cloves (Syzygium aromaticum) have been used as a traditional Chinese medicinal herb for
thousands of years. Cloves possess antiseptic, antibacterial, antifungal, and antiviral …