This review provides an updated summary of the state of our knowledge of the genetic
contributions to the pathogenesis of congenital heart disease. Since 2007, when the initial …

Congenital heart disease (CHD) is one of the most common birth defects. Studies in animal
models and humans have indicated a genetic etiology for CHD. About 400 genes have been …

2018 AHA/ACC Guideline for the Management of Adults With Congenital Heart Disease: A
Report of the American College of Cardiology/American Heart Association Task Force on …

The recommendations listed in this guideline are, whenever possible, evidence-based. An
initial extensive evidence review, which included literature derived from research involving …

The neural crest (NC) is a transient, multipotent and migratory cell population that generates
an astonishingly diverse array of cell types during vertebrate development. These cells …

Mechanical forces are well known for modulating heart valve developmental programs. Yet,
it is still unclear how genetic programs and mechanosensation interact during heart valve …

Placental abnormalities have been sporadically implicated as a source of developmental
heart defects. Yet it remains unknown how often the placenta is at the root of congenital …

Congenital heart disease (CHD) is the most common type of birth defect and is both a
significant pediatric and adult health problem, in light of a growing population of survivors …

Congenital heart disease (CHD) is the most common human birth defect and remains a
leading cause of mortality in childhood. Although advances in clinical management have …

Hemodynamic forces play an essential epigenetic role in heart valve development, but how
they do so is not known. Here, we show that the shear-responsive transcription factor KLF2 …