The prevalence of obesity has tripled over the past four decades, imposing an enormous
burden on people's health. Polygenic (or common) obesity and rare, severe, early-onset …

Genome-wide association studies (GWAS) involve testing genetic variants across the
genomes of many individuals to identify genotype–phenotype associations. GWAS have …

Abstract Background and Aims The risk factors of cholelithiasis have not been clearly
identified, especially for total cholesterol. Here, we try to identify these causal risk factors …

The mechanism of insulin action is a central theme in biology and medicine. In addition to
the rather rare condition of insulin deficiency caused by autoimmune destruction of …

Background Type 2 diabetes (T2D) is a heterogeneous disease for which (1) disease-
causing pathways are incompletely understood and (2) subclassification may improve …

With the increasing availability of large-scale GWAS summary data on various complex traits
and diseases, there have been tremendous interests in applications of Mendelian …

Physical activity and sleep duration are established risk factors for many diseases, but their
aetiology is poorly understood, partly due to relying on self-reported evidence. Here we …

Insulin resistance is a key mediator of obesity-related cardiometabolic disease, yet the
mechanisms underlying this link remain obscure. Using an integrative genomic approach …

There is a genetic component to human obesity that accounts for 40% to 50% of the
variability in body weight status but that is lower among normal weight individuals (about …

With the increasing availability of large-scale GWAS summary data on various traits,
Mendelian randomization (MR) has become commonly used to infer causality between a …