The gastrointestinal tract has recently come to the forefront of multiple research fields. It is
now recognized as a major source of signals modulating food intake, insulin secretion and …

Polyploid cells, which contain multiple copies of the typically diploid genome, are
widespread in plants and animals. Polyploidization can be developmentally programmed or …

Adverse cardiac remodeling after myocardial infarction (MI) causes structural and functional
changes in the heart leading to heart failure. The initial post-MI pro-inflammatory response …

The JAK/STAT pathway is a conserved metazoan signaling system that transduces cues
from extracellular cytokines into transcriptional changes in the nucleus. JAK/STAT signaling …

Infections and neurodegenerative diseases induce neuroinflammation, but affected
individuals often show nonneural symptoms including muscle pain and muscle fatigue. The …

Since its discovery, the Hippo pathway has emerged as a central signaling network in
mammalian cells. Canonical signaling through the Hippo pathway core components …

JNK signaling is a critical regulator of inflammation and regeneration, but how it is controlled
in specific tissue contexts remains unclear. Here we show that, in the Drosophila intestine …

Gut microbes play important roles in host physiology; however, the mechanisms underlying
their impact remain poorly characterized. Here, we demonstrate that microbes not only …

In adult insects, as in vertebrates, the gut epithelium is a highly regenerative tissue that can
renew itself rapidly in response to changing inputs from nutrition, the gut microbiota …

From flies to humans, many components of the innate immune system have been conserved
during metazoan evolution. This foundational observation has allowed us to develop …