Molecular oxygen (O2) is essential for most biological reactions in mammalian cells. When
the intracellular oxygen content decreases, it is called hypoxia. The process of hypoxia is …

Alzheimer's disease (AD) was described in 1906 as a dementing disease marked by the
presence of two types of fibrillar aggregates in the brain: neurofibrillary tangles and senile …

Dysregulation of factors in nucleocytoplasmic transport is closely linked to neural
developmental diseases. Mutation in Hikeshi, encoding a nonconventional nuclear import …

Alzheimer's disease (AD) represents one of the most common and debilitating
neurodegenerative disorders. By the end of 2040, AD patients might reach 11.2 million in …

The nuclear membrane serves a critical role in protecting the contents of the nucleus and
facilitating material and signal exchange between the nucleus and cytoplasm. While …

Immunogold labeling allows localization of proteins at the electron microscopy (EM) level of
resolution, and quantification of signals. The present paper summarizes methodological …

The nuclear pore complex (NPC) has long been assumed to be the sole route across the
nuclear envelope, and under normal homeostatic conditions it is indeed the main …

Transport from and into the nucleus is essential to all eukaryotic life and occurs through the
nuclear pore complex (NPC). There are a multitude of data supporting a role for nuclear …

Organelles are specialized subunits within cells which carry out vital functions crucial to
cellular survival and form a tightly regulated network. Dysfunctions in any of these …

Small extracellular vesicle (sEV)-mediated intercellular communication regulates multiple
aspects of growth and development in multicellular organisms. However, the mechanism …