An ever-increasing demand for novel antimicrobials to treat life-threatening infections
caused by the global spread of multidrug-resistant bacterial pathogens stands in stark …

Hydroxyquinoline (8-HQ) is a significant heterocyclic scaffold in organic and analytical
chemistry because of the properties of chromophore and is used to detect various metal ions …

The search for new antimicrobials is imperative due to the emergent resistance of new
microorganism strains. In this context, revisiting known classes like 8-hydroxyquinolines …

Sirtuin 1 (SIRT1) enzyme plays a pivotal role in the regulation of many physiological
functions. In particular, it is implicated in ageing‐related diseases, such as cardiac …

Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterized by a
progressive-fibrosing phenotype. IPF has been associated with aberrant HDAC activities …

The ever-increasing incidence of drug-resistant Mycobacterium tuberculosis infections has
invigorated the focus on the discovery and development of novel treatment options. The …

Identification of pathogens and diagnosis of infections are important health challenges,
especially in the case of fastidious bacteria which are those difficult-to-grow. A fastidious …

The p53 protein, also called guardian of the genome, plays a critical role in the cell cycle
regulation and apoptosis. This protein is frequently inactivated in several types of human …

Tuberculosis (TB) is one of the top 10 causes of death worldwide. This scenario is further
complicated by the insurgence of multidrug-resistant (MDR) and extensively drug-resistant …

We describe herein the development and experimental validation of a computational
protocol for optimizing a series of 3-hydroxy-pyran-4-one derivatives as HIV integrase …