Cardiac fibrosis remains an unresolved problem in heart diseases. After initial injury, cardiac
fibroblasts (CFs) are activated and subsequently differentiate into myofibroblasts (myoFbs) …

The liver is a central organ for homeostasis with unique regenerative capacities. Mature
hepatocytes possess a remarkable capacity to proliferate upon injury, challenging efforts to …

β-thalassemia, one of the most common genetic diseases worldwide, is caused by mutations
in the human hemoglobin beta (HBB) gene. Creation of human induced pluripotent stem …

The direct lineage reprogramming of one specialized cell type into another using defined
factors has fundamentally re-shaped traditional concepts regarding the epigenetic stability of …

The field of regenerative medicine aims to replace tissues lost as a consequence of disease,
trauma or congenital abnormalities. Biomaterials serve as scaffolds for regenerative …

We have recently demonstrated that reactive glial cells can be directly reprogrammed into
functional neurons by a single neural transcription factor, NeuroD1. Here we report that a …

Pancreatic beta cells are of great interest for biomedical research and regenerative
medicine. Here we show the conversion of human fibroblasts towards an endodermal cell …

It was recently shown that mouse fibroblasts could be reprogrammed into cells of a cardiac
fate by forced expression of multiple transcription factors and microRNAs. For ultimate …

Pluripotency reprogramming and transdifferentiation induced by transcription factors can
generate induced pluripotent stem cells, adult stem cells or specialized cells. However, the …

Background Epigenetic alterations including DNA methylation and histone modifications are
the key factors in the differentiation of stem cells into different tissue subtypes. The …