Type 2 diabetes (T2D) is a complex disease that is caused by a complex interplay between
genetic, epigenetic and environmental factors. While the major environmental factors, diet …

Gap junctions are essential to the function of multicellular animals, which require a high
degree of coordination between cells. In vertebrates, gap junctions comprise connexins and …

Following the identification of several disease-associated polymorphisms by genome-wide
association (GWA) analysis, interest is now focusing on the detection of effects that, owing to …

Epistasis, the interaction between genes, is a topic of current interest in molecular and
quantitative genetics. A large amount of research has been devoted to the detection and …

▪ Abstract Phenotypic variation for quantitative traits results from the segregation of alleles at
multiple quantitative trait loci (QTL) with effects that are sensitive to the genetic, sexual, and …

Interactions among loci or between genes and environmental factors make a substantial
contribution to variation in complex traits such as disease susceptibility. Nonetheless, many …

Type 2 or non-insulin-dependent diabetes mellitus (NIDDM) is the most common form of
diabetes worldwide, affecting approximately 4% of the world's adult population. It is …

Assessing the association between DNA variants and disease has been used widely to
identify regions of the genome and candidate genes that contribute to disease. However …

We often think of neurodevelopmental disorders as beginning before birth, and many
certainly do. A handful, however, strike many months after birth, following a period of …

Diabetes mellitus is one of the most common endocrine disorders affecting almost 6% of the
world's population. The number of diabetic patients will reach 300 million in 2025 …