A Review of the Important Role of CYP2D6 in Pharmacogenomics
C Taylor, I Crosby, V Yip, P Maguire, M Pirmohamed… - Genes, 2020 - mdpi.com
Cytochrome P450 2D6 (CYP2D6) is a critical pharmacogene involved in the metabolism of~
20% of commonly used drugs across a broad spectrum of medical disciplines including …
20% of commonly used drugs across a broad spectrum of medical disciplines including …
PharmVar GeneFocus: CYP2D6
C Nofziger, AJ Turner, K Sangkuhl… - Clinical …, 2020 - Wiley Online Library
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly
polymorphic human CYP2D6 gene locus. CYP2D6 genetic variation impacts the metabolism …
polymorphic human CYP2D6 gene locus. CYP2D6 genetic variation impacts the metabolism …
Prediction of CYP2D6 phenotype from genotype across world populations
A Gaedigk, K Sangkuhl, M Whirl-Carrillo, T Klein… - Genetics in …, 2017 - nature.com
Purpose: Owing to its highly polymorphic nature and major contribution to the metabolism
and bioactivation of numerous clinically used drugs, CYP2D6 is one of the most extensively …
and bioactivation of numerous clinically used drugs, CYP2D6 is one of the most extensively …
The genetic landscape of major drug metabolizing cytochrome P450 genes—an updated analysis of population-scale sequencing data
Y Zhou, VM Lauschke - The Pharmacogenomics Journal, 2022 - nature.com
Genes encoding cytochrome P450 enzymes (CYPs) are extremely polymorphic and multiple
CYP variants constitute clinically relevant biomarkers for the guidance of drug selection and …
CYP variants constitute clinically relevant biomarkers for the guidance of drug selection and …
PharmVar GeneFocus: CYP2C19
MR Botton, M Whirl‐Carrillo… - Clinical …, 2021 - Wiley Online Library
The Pharmacogene Variation Consortium (PharmVar) catalogues star (*) allele
nomenclature for the polymorphic human CYP2C19 gene. CYP2C19 genetic variation …
nomenclature for the polymorphic human CYP2C19 gene. CYP2C19 genetic variation …
[HTML][HTML] Recommendations for clinical CYP2D6 genotyping allele selection: a joint consensus recommendation of the Association for Molecular Pathology, College of …
VM Pratt, LH Cavallari, AL Del Tredici… - The Journal of Molecular …, 2021 - Elsevier
The goals of the Association for Molecular Pathology Clinical Practice Committee's
Pharmacogenomics (PGx) Working Group are to define the key attributes of …
Pharmacogenomics (PGx) Working Group are to define the key attributes of …
Pharmacogenetics at scale: an analysis of the UK Biobank
Pharmacogenetics (PGx) studies the influence of genetic variation on drug response.
Clinically actionable associations inform guidelines created by the Clinical …
Clinically actionable associations inform guidelines created by the Clinical …
The evolution of PharmVar
A Gaedigk, K Sangkuhl… - Clinical …, 2018 - pmc.ncbi.nlm.nih.gov
The Pharmacogene Variation Consortium (PharmVar) continues the mission of the Human
Cytochrome P450 (CYP) Nomenclature database to provide the clinical and research …
Cytochrome P450 (CYP) Nomenclature database to provide the clinical and research …
Sequencing the CYP2D6 Gene: From Variant Allele Discovery to Clinical Pharmacogenetic Testing
CYP2D6 is one of the most studied enzymes in the field of pharmacogenetics. The CYP2D6
gene is highly polymorphic with over 100 catalogued star (*) alleles, and clinical CYP2D6 …
gene is highly polymorphic with over 100 catalogued star (*) alleles, and clinical CYP2D6 …
[HTML][HTML] Stargazer: a software tool for calling star alleles from next-generation sequencing data using CYP2D6 as a model
S Lee, MM Wheeler, K Patterson, S McGee, R Dalton… - Genetics in …, 2019 - Elsevier
Abstract Purpose Genotyping CYP2D6 is important for precision drug therapy because the
enzyme it encodes metabolizes approximately 25% of drugs, and its activity varies …
enzyme it encodes metabolizes approximately 25% of drugs, and its activity varies …