Dietary regulation in health and disease

Q Wu, ZJ Gao, X Yu, P Wang - Signal Transduction and Targeted …, 2022 - nature.com
Nutriments have been deemed to impact all physiopathologic processes. Recent evidences
in molecular medicine and clinical trials have demonstrated that adequate nutrition …

tRNA dysregulation and disease

EA Orellana, E Siegal, RI Gregory - Nature Reviews Genetics, 2022 - nature.com
Abstract tRNAs are key adaptor molecules that decipher the genetic code during translation
of mRNAs in protein synthesis. In contrast to the traditional view of tRNAs as ubiquitously …

Metabolic pathway analysis using stable isotopes in patients with cancer

CR Bartman, B Faubert, JD Rabinowitz… - Nature Reviews …, 2023 - nature.com
Metabolic reprogramming is central to malignant transformation and cancer cell growth. How
tumours use nutrients and the relative rates of reprogrammed pathways are areas of intense …

Transfer RNAs as dynamic and critical regulators of cancer progression

AM Pinzaru, SF Tavazoie - Nature Reviews Cancer, 2023 - nature.com
Transfer RNAs (tRNAs) have been historically viewed as non-dynamic adaptors that decode
the genetic code into proteins. Recent work has uncovered dynamic regulatory roles for …

Real-time detection of 20 amino acids and discrimination of pathologically relevant peptides with functionalized nanopore

M Zhang, C Tang, Z Wang, S Chen, D Zhang, K Li… - Nature …, 2024 - nature.com
Precise identification and quantification of amino acids is crucial for many biological
applications. Here we report a copper (II)-functionalized Mycobacterium smegmatis porin A …

Protein restriction and branched‐chain amino acid restriction promote geroprotective shifts in metabolism

ME Trautman, NE Richardson, DW Lamming - Aging cell, 2022 - Wiley Online Library
The proportion of humans suffering from age‐related diseases is increasing around the
world, and creative solutions are needed to promote healthy longevity. Recent work has …

Arginine limitation drives a directed codon-dependent DNA sequence evolution response in colorectal cancer cells

DJ Hsu, J Gao, N Yamaguchi, A Pinzaru, Q Wu… - Science …, 2023 - science.org
Utilization of specific codons varies between organisms. Cancer represents a model for
understanding DNA sequence evolution and could reveal causal factors underlying codon …

Human HDAC6 senses valine abundancy to regulate DNA damage

J Jin, T Meng, Y Yu, S Wu, CC Jiao, S Song, YX Li… - Nature, 2024 - nature.com
As an essential branched amino acid, valine is pivotal for protein synthesis, neurological
behaviour, haematopoiesis and leukaemia progression,–. However, the mechanism by …

Emerging roles of tRNA in cancer

D Ren, Y Mo, M Yang, D Wang, Y Wang, Q Yan, C Guo… - Cancer Letters, 2023 - Elsevier
Transfer RNAs (tRNAs) play pivotal roles in the transmission of genetic information, and
abnormality of tRNAs directly leads to translation disorders and causes diseases, including …

Translation efficiency driven by CNOT3 subunit of the CCR4-NOT complex promotes leukemogenesis

M Ghashghaei, Y Liu, J Ettles, G Bombaci… - Nature …, 2024 - nature.com
Protein synthesis is frequently deregulated during tumorigenesis. However, the precise
contexts of selective translational control and the regulators of such mechanisms in cancer is …