Advances of nanoparticles as drug delivery systems for disease diagnosis and treatment

R Liu, C Luo, Z Pang, J Zhang, S Ruan, M Wu… - Chinese chemical …, 2023 - Elsevier
Decades have passed since the first nanoparticles-base medicine was approved for human
cancer treatment, and the research and development of nanoparticles for drug delivery are …

Advances in oral peptide therapeutics

DJ Drucker - Nature reviews Drug discovery, 2020 - nature.com
Protein and peptide therapeutics require parenteral administration, which can be a deterrent
to medication adherence. For this reason, there have been extensive efforts to develop …

Underestimated health risks: polystyrene micro-and nanoplastics jointly induce intestinal barrier dysfunction by ROS-mediated epithelial cell apoptosis

B Liang, Y Zhong, Y Huang, X Lin, J Liu, L Lin… - Particle and fibre …, 2021 - Springer
Background Micro-and nanoplastic pollution has become a global environmental problem.
Nanoplastics in the environment are still hard to detect because of analysis technology …

Advances in oral drug delivery for regional targeting in the gastrointestinal tract-influence of physiological, pathophysiological and pharmaceutical factors

S Hua - Frontiers in pharmacology, 2020 - frontiersin.org
The oral route is by far the most common route of drug administration in the gastrointestinal
tract and can be used for both systemic drug delivery and for treating local gastrointestinal …

Food-derived bioactive peptides in human health: Challenges and opportunities

S Chakrabarti, S Guha, K Majumder - Nutrients, 2018 - mdpi.com
Recent scientific evidence suggests that food proteins not only serve as nutrients, but can
also modulate the body's physiological functions. These physiological functions are primarily …

Blue-ringed octopus-inspired microneedle patch for robust tissue surface adhesion and active injection drug delivery

Z Zhu, J Wang, X Pei, J Chen, X Wei, Y Liu, P Xia… - Science …, 2023 - science.org
Intratissue topical medication is important for the treatment of cutaneous, mucosal or
splanchnic diseases. However, penetrating surface barriers to providing adequate and …

[HTML][HTML] Oral delivery of proteins and peptides: Challenges, status quo and future perspectives

Q Zhu, Z Chen, PK Paul, Y Lu, W Wu, J Qi - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Proteins and peptides (PPs) have gradually become more attractive therapeutic molecules
than small molecular drugs due to their high selectivity and efficacy, but fewer side effects …

Mechanisms of nanoparticle transport across intestinal tissue: an oral delivery perspective

SA Ejazi, R Louisthelmy, K Maisel - ACS nano, 2023 - ACS Publications
Oral drug administration has been a popular choice due to patient compliance and limited
clinical resources. Orally delivered drugs must circumvent the harsh gastrointestinal (GI) …

Protein digestibility of cereal products

I Joye - Foods, 2019 - mdpi.com
Protein digestibility is currently a hot research topic and is of big interest to the food industry.
Different scoring methods have been developed to describe protein quality. Cereal protein …

Oxygen battle in the gut: Hypoxia and hypoxia-inducible factors in metabolic and inflammatory responses in the intestine

R Singhal, YM Shah - Journal of Biological Chemistry, 2020 - ASBMB
The gastrointestinal tract is a highly proliferative and regenerative tissue. The intestine also
harbors a large and diverse microbial population collectively called the gut microbiome …