Pyridazinone is an unexplored scaffold in the literature, yet it is an essential motif in the
design and development of novel drugs. Recently, it has attracted several medicinal …

Herein, the mono and dialkylation of pyridazino [4, 5-b] indole were achieved with a set of
alkylating agents, including amyl bromide, allyl bromide, benzyl bromide and ethyl …

The reaction of benzocyclic norbornene derivatives with tetrazines provided the 1, 3‐
dihydropyridazine derivatives as a single product. The dihydropyridazine derivatives have …

Polycyclic N-heterocycles are important structural motifs commonly found in bioactive
compounds, however, their selective construction via the cyclization of allenynes remains …

The hit compound 1, 2, 4-triazolo [4', 3': 2, 3] pyridazino [4, 5-b] indole 3 was synthesized
from the reflux of 4-amino-5-indolyl-1, 2, 4-triazole-3-thione 1 with 4′-bromoacetophenone …

Abstract Cu (II), Co (II), Ni (II) and Zn (II) complexes of ligands 5-substituted-N′-((7-hydroxy-
4-methyl-2-oxo-2H-chromen-8-yl) methylene)-3-phenyl-1H-indole-2-carbohydrazides were …

Metal-free rapid access to pyrrole-2, 3-dione has been developed under mild conditions
from easily available materials, which was utilized to synthesize pyrrolo [2, 3-d] pyridazin-7 …

The alkylation of 3, 5-dihydro-4H-pyridazino [4, 5-b] indole-4-thione with benzyl bromide,
ethyl chloroacetate, and allyl bromide in the presence of potassium carbonate (K2CO3) …

Abstract The nucleus of pyridazino [4, 5-b] indoles contains two heterocyclic moieties that
interact with many receptors. They are an important class of heterocyclic compounds with …

Abstract Pyridazino [4, 5-b] indole is an important class of heterocyclic compounds with
numerous applications in the field of medicinal chemistry. This review summarizes the …