[HTML][HTML] Proper animal experimental designs for preclinical research of biomaterials for intervertebral disc regeneration
Y Peng, X Qing, H Shu, S Tian, W Yang… - Biomaterials …, 2021 - ncbi.nlm.nih.gov
Low back pain is a vital musculoskeletal disease that impairs life quality, leads to disability
and imposes heavy economic burden on the society, while it is greatly attributed to …
and imposes heavy economic burden on the society, while it is greatly attributed to …
Development of a standardized histopathology scoring system for intervertebral disc degeneration in rat models: An initiative of the ORS spine section
Background Rats are a widely accepted preclinical model for evaluating intervertebral disc
(IVD) degeneration and regeneration. IVD morphology is commonly assessed using …
(IVD) degeneration and regeneration. IVD morphology is commonly assessed using …
In vivo Mouse Intervertebral Disc Degeneration Models and Their Utility as Translational Models of Clinical Discogenic Back Pain: A Comparative Review
Low back pain is a leading cause of disability worldwide and studies have demonstrated
intervertebral disc (IVD) degeneration as a major risk factor. While many in vitro models …
intervertebral disc (IVD) degeneration as a major risk factor. While many in vitro models …
High‐Strength Smart Microneedles with “Offensive and Defensive” Effects for Intervertebral Disc Repair
Q Meng, E Xie, H Sun, H Wang, J Li, Z Liu… - Advanced …, 2024 - Wiley Online Library
Intervertebral disc degeneration (IVDD) is a global public health issue. The injury of annulus
fibrosus (AF) caused by acupuncture or discectomy can trigger IVDD again. However, there …
fibrosus (AF) caused by acupuncture or discectomy can trigger IVDD again. However, there …
Males and females exhibit distinct relationships between intervertebral disc degeneration and pain in a rat model
Back pain is linked to intervertebral disc (IVD) degeneration, but clinical studies show the
relationship is complex. This study assessed whether males and females have distinct …
relationship is complex. This study assessed whether males and females have distinct …
Roadmap on biomaterials for women's health
The application of engineering tools and techniques to studying women's health, including
biomaterials-based approaches, is a research field experiencing robust growth. Biomaterials …
biomaterials-based approaches, is a research field experiencing robust growth. Biomaterials …
[HTML][HTML] Non-viral reprogramming of human nucleus pulposus cells with FOXF1 via extracellular vesicle delivery: an in vitro and in vivo study
S Tang, A Salazar-Puerta, J Richards… - European cells & …, 2021 - ncbi.nlm.nih.gov
Intervertebral disc (IVD) degeneration is characterized by decreased cellularity and
proteoglycan synthesis and increased inflammation, catabolism, and neural/vascular …
proteoglycan synthesis and increased inflammation, catabolism, and neural/vascular …
Spinal cord sensitization and spinal inflammation from an in vivo rat endplate injury associated with painful intervertebral disc degeneration
Intervertebral disc (IVD) degeneration with Modic-like changes is strongly associated with
pain. Lack of effective disease-modifying treatments for IVDs with endplate (EP) defects …
pain. Lack of effective disease-modifying treatments for IVDs with endplate (EP) defects …
Ex-vivo biomechanics of repaired rat intervertebral discs using genipin crosslinked fibrin adhesive hydrogel
Microdiscectomy is the current standard surgical treatment for intervertebral disc (IVD)
herniation, however annulus fibrosus (AF) defects remain unrepaired which can alter IVD …
herniation, however annulus fibrosus (AF) defects remain unrepaired which can alter IVD …
Mulberroside A mitigates intervertebral disc degeneration by inhibiting MAPK and modulating Ppar-γ/NF-κB pathways
T Xu, H Zhao, X Fang, S Wang, J Li, H Wu, W Hu… - Journal of …, 2024 - Springer
Background Intervertebral disc degeneration (IVDD) is a common spine disease with
inflammation as its main pathogenesis. Mulberroside A (MA), isolated from herbal medicine …
inflammation as its main pathogenesis. Mulberroside A (MA), isolated from herbal medicine …