Targeting integrin pathways: mechanisms and advances in therapy

X Pang, X He, Z Qiu, H Zhang, R Xie, Z Liu… - … and Targeted Therapy, 2023 - nature.com
Integrins are considered the main cell-adhesion transmembrane receptors that play
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …

[HTML][HTML] Progress in targeting PTEN/PI3K/Akt axis in glioblastoma therapy: Revisiting molecular interactions

M Hashemi, S Etemad, S Rezaei, S Ziaolhagh… - Biomedicine & …, 2023 - Elsevier
Glioblastoma (GBM) is one of the most malignant cancers of central nervous system and due
to its sensitive location, surgical resection has high risk and therefore, chemotherapy and …

Disulfidptosis classification of hepatocellular carcinoma reveals correlation with clinical prognosis and immune profile

T Wang, K Guo, D Zhang, H Wang, J Yin, H Cui… - International …, 2023 - Elsevier
A new mode of cell death, disulfidptosis, has been discovered. Clinical prognostic
significance of disulfidptosis related pattern in hepatocellular carcinoma (HCC). In this study …

Antiandrogen treatment induces stromal cell reprogramming to promote castration resistance in prostate cancer

H Wang, N Li, Q Liu, J Guo, Q Pan, B Cheng, J Xu… - Cancer Cell, 2023 - cell.com
Lineage plasticity causes therapeutic resistance; however, it remains unclear how the fate
conversion and phenotype switching of cancer-associated fibroblasts (CAFs) are implicated …

Identification of anoikis-related subgroups and prognosis model in liver hepatocellular carcinoma

Y Chen, W Huang, J Ouyang, J Wang, Z Xie - International journal of …, 2023 - mdpi.com
Resistance to anoikis is a key characteristic of many cancer cells, promoting cell survival.
However, the mechanism of anoikis in hepatocellular carcinoma (HCC) remains unknown …

Targeting PI3K/Akt signaling in prostate cancer therapy

M Hashemi, A Taheriazam, P Daneii… - Journal of Cell …, 2023 - Springer
Urological cancers have obtained much attention in recent years due to their mortality and
morbidity. The most common and malignant tumor of urological cancers is prostate cancer …

Molecular panorama of therapy resistance in prostate cancer: a pre-clinical and bioinformatics analysis for clinical translation

M Ashrafizadeh, W Zhang, Y Tian, G Sethi… - Cancer and Metastasis …, 2024 - Springer
Prostate cancer (PCa) is a malignant disorder of prostate gland being asymptomatic in early
stages and high metastatic potential in advanced stages. The chemotherapy and surgical …

Acute myeloid leukemia (AML)‐derived mesenchymal stem cells induce chemoresistance and epithelial–mesenchymal transition‐like program in AML through IL‐6 …

J Lu, Q Dong, S Zhang, Y Feng, J Yang… - Cancer …, 2023 - Wiley Online Library
Acute myeloid leukemia (AML) has a high rate of treatment failure due to increased
prevalence of therapy resistance. Mesenchymal stem cells (MSCs) in the leukemia …

[HTML][HTML] A comprehensive analysis of single-cell RNA transcriptome reveals unique SPP1+ chondrocytes in human osteoarthritis

Y Qu, Y Wang, S Wang, X Yu, Y He, R Lu… - Computers in Biology …, 2023 - Elsevier
Osteoarthritis (OA) has become the most common degenerative disease in the world, which
brings a serious economic burden to society and the country. Although epidemiological …

New insight in urological cancer therapy: From epithelial-mesenchymal transition (EMT) to application of nano-biomaterials

P He, Q Dai, X Wu - Environmental Research, 2023 - Elsevier
A high number of cancer-related deaths (up to 90) are due to metastasis and simple
definition of metastasis is new colony formation of tumor cells in a secondary site. In tumor …