Obesity is a chronic, relapsing condition characterized by excess body fat. Its prevalence
has increased globally since the 1970s, and the number of obese and overweight people is …

Obesity is a worldwide epidemic that predisposes individuals to cardiometabolic
complications, such as type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease …

In mammals, excess energy is stored primarily as triglycerides, which are mobilized when
energy demands arise. This review mainly focuses on the role of long chain fatty acids …

Brain cells normally respond adaptively to oxidative stress or bioenergetic challenges,
resulting from ongoing activity in neuronal circuits. During aging and in neurodegenerative …

Cells are constantly exposed to a large variety of lipids. Traditionally, these molecules were
thought to serve as simple energy storing molecules. More recently it has been realized that …

▪ Abstract The peroxisome proliferator-activated receptors (PPARs) are a group of three
nuclear receptor isoforms, PPARγ, PPARα, and PPARδ, encoded by different genes. PPARs …

Highly potent, but poorly water-soluble, drug candidates are common outcomes of
contemporary drug discovery programmes and present a number of challenges to drug …

The peroxisome proliferator activated receptors (PPARs) are nuclear receptors that play key
roles in the regulation of lipid metabolism, inflammation, cellular growth, and differentiation …

Obesity and the related disorders of dyslipidemia and diabetes (components of syndrome X)
have become global health epidemics. Over the past decade, the elucidation of key …

Cholesterol, fatty acids, fat-soluble vitamins, and other lipids present in our diets are not only
nutritionally important but serve as precursors for ligands that bind to receptors in the …