The immunology of Plasmodium vivax malaria

LR Antonelli, C Junqueira, JM Vinetz… - Immunological …, 2020 - Wiley Online Library
Plasmodium vivax infection, the predominant cause of malaria in Asia and Latin America,
affects~ 14 million individuals annually, with considerable adverse effects on wellbeing and …

Plasmodium vivax vaccine: What is the best way to go?

GTS Veiga, MR Moriggi, JF Vettorazzi… - Frontiers in …, 2023 - frontiersin.org
Malaria is one of the most devastating human infectious diseases caused by Plasmodium
spp. parasites. A search for an effective and safe vaccine is the main challenge for its …

Plasmodium vivax Latent Liver Stage Infection and Relapse: Biological Insights and New Experimental Tools

C Schäfer, G Zanghi, AM Vaughan… - Annual Review of …, 2021 - annualreviews.org
Plasmodium vivax is the most widespread human malaria parasite, in part because it can
form latent liver stages known as hypnozoites after transmission by female anopheline …

Diagnosis of Malaria Parasites Plasmodium spp. in Endemic Areas: Current Strategies for an Ancient Disease

B Gitta, N Kilian - BioEssays, 2020 - Wiley Online Library
Fast and effective detection of the causative agent of malaria in humans, protozoan
Plasmodium parasites, is of crucial importance for increasing the effectiveness of treatment …

Translating diagnostics and drug delivery technologies to low-resource settings

EM Euliano, AA Sklavounos, AR Wheeler… - Science translational …, 2022 - science.org
Diagnostics and drug delivery technologies engineered for low-resource settings aim to
meet their technical design specifications using strategies that are compatible with limited …

Monoclonal antibodies for malaria prevention

M Aleshnick, M Florez-Cuadros, T Martinson… - Molecular Therapy, 2022 - cell.com
Monoclonal antibodies are highly specific proteins that are cloned from a single B cell and
bind to a single epitope on a pathogen. These laboratory-made molecules can serve as …

Progress towards the development of a P. vivax vaccine

SL De, FB Ntumngia, J Nicholas… - Expert review of …, 2021 - Taylor & Francis
Introduction Plasmodium vivax causes significant public health problems in endemic
regions. A vaccine to prevent disease is critical, considering the rapid spread of drug …

Naturally acquired antibodies against Plasmodium vivax pre-erythrocytic stage vaccine antigens inhibit sporozoite invasion of human hepatocytes in vitro

FB Ntumngia, SK Kolli, P Annamalai Subramani… - Scientific Reports, 2024 - nature.com
In Plasmodium vivax, the most studied vaccine antigens are aimed at blocking merozoite
invasion of erythrocytes and disease development. Very few studies have evaluated pre …

Preliminary characterization of Plasmodium vivax sporozoite antigens as pre-erythrocytic vaccine candidates

J Nicholas, SL De, P Thawornpan… - PLoS Neglected …, 2023 - journals.plos.org
Plasmodium vivax pre-erythrocytic (PE) vaccine research has lagged far behind efforts to
develop Plasmodium falciparum vaccines. There is a critical gap in our knowledge of PE …

Plasmodium vivax Duffy Binding Protein-Based Vaccine: a Distant Dream

S Kar, A Sinha - Frontiers in Cellular and Infection Microbiology, 2022 - frontiersin.org
The neglected but highly prevalent Plasmodium vivax in South-east Asia and South America
poses a great challenge, with regards to long-term in-vitro culturing and heavily limited …