Activation of telomerase is a critical step in the development of about 85% of human
cancers. Levels of Tert, which encodes the reverse transcriptase subunit of telomerase, are …

purpose: The purpose of this article is to present an overview of the epidemiology diagnosis,
and management of bladder cancer, with a focus on the early stage of this disease …

Two cyclooxygenase isozymes, COX-1 and-2, are known to catalyze the rate-limiting step of
prostaglandin synthesis and are the targets of nonsteroidal antiinflammatory drugs. Here we …

The telomerase reverse transcriptase (TERT) promoter, an important element of telomerase
expression, has emerged as a target of cancer-specific mutations. Originally described in …

Aims/hypothesis In the light of a report suggesting that insulin glargine may increase cancer
occurrence, the EASD asked us to perform this study. Methods We followed 114,841 …

We investigated the association of urinary bladder cancer with genetic polymorphisms in the
xeroderma pigmentosum complementation group C (XPC), group D (XPD) and group G …

Abstract Background Consumption of Chinese herbs that contain aristolochic acid (eg, Mu
Tong) has been associated with an increased risk of urinary tract cancer. Methods We …

Uncontrolled self-renewal plays a direct function in the progression of different types of
carcinomas. The same molecular pathway that manages self-renewal in normal stem cells …

Inorganic arsenic (iAs) at high exposures is a human carcinogen, affecting mainly the
urinary bladder, lung and skin. We present an assessment of the mode of action (MOA) of …

Transitional cell (urothelial) carcinoma of the bladder is the second most common urologic
malignancy and is one of the best understood neoplasms, with relatively well-defined …