Importance Cirrhosis affects approximately 2.2 million adults in the US. From 2010 to 2021,
the annual age-adjusted mortality of cirrhosis increased from 14.9 per 100 000 to 21.9 per …

In patients with cirrhosis and chronic liver disease, acute-on-chronic liver failure is emerging
as a major cause of mortality. These guidelines indicate the preferred approach to the …

This AASLD Guidance provides a data-supported approach to the management of ascites
and HRS. It differs from the AASLD Guidelines, which are supported by systematic reviews …

The natural history of cirrhosis is characterised by an asymptomatic compensated phase
followed by a decompensated phase, marked by the development of overt clinical signs, the …

The British Society of Gastroenterology in collaboration with British Association for the Study
of the Liver has prepared this document. The aim of this guideline is to review and …

Background & Aims Bacterial infections are common and life-threatening in patients with
cirrhosis. Little is known about the epidemiology of bacterial infections in different regions …

Background Infection and increased systemic inflammation cause organ dysfunction and
death in patients with decompensated cirrhosis. Preclinical studies provide support for an …

Sepsis and septic shock are characterized by life-threatening organ dysfunction caused by a
dysregulated host response to infection. The liver has a central role during sepsis, and is …

Background & Aims Antibiotic resistance has been increasingly reported in patients with
decompensated cirrhosis in single-center studies. Prospective investigations reporting …

Bacterial infections are frequent in cirrhotic patients with acute decompensation or acute-on-
chronic liver failure and can complicate the clinical course. Delayed diagnosis and …