Cyclooxygenases play a vital role in inflammation and are responsible for the production of
prostaglandins. Two cyclooxygenases are described, the constitutive cyclooxygenase-1 and …

Tetrazole derivatives are a prime class of heterocycles, very important to medicinal
chemistry and drug design due to not only their bioisosterism to carboxylic acid and amide …

Tetrazoles represent a class of five-membered heterocyclic compounds with polynitrogen
electron-rich planar structural features. This special structure makes tetrazole derivatives …

The tetrazole ring is an important pharmacophore. It is a structural component in many
drugs, drug candidates (or lead compounds) and various biochemical reagents. This review …

In the recent past, the design and synthesis of peptide mimics (peptidomimetics) has
received much attention. This because they have shown in many cases enhanced …

This report provides a brief overview of the various representative literature procedures for
the synthesis of 1, 5-disubstituted tetrazoles (1, 5-DSTs) and fused 1, 5-disubstituted …

Heterocyclic compounds are important organic compounds and have emerged as key
scaffolds in numerous drugs, natural products, vitamins, biologically and pharmaceutically …

Background In this article, a series of 20 new thiosemicarbazone derivatives containing
indole were synthesized and evaluated for their anti-inflammatory potential. Methods The …

Inflammation is a complex phenomenon necessary in human defense mechanisms but also
involved in the development of some human diseases. The discovery of cyclooxygenase-2 …

Two series of new thiazolidin-4-one derivatives 4a–c and 8a–e were designed and
prepared. All the synthesized compounds were evaluated for their in vitro COX-2 selectivity …