The disease burden associated with overweight and obesity

A Must, J Spadano, EH Coakley, AE Field, G Colditz… - Jama, 1999 - jamanetwork.com
ContextOverweight and obesity are increasing dramatically in the United States and most
likely contribute substantially to the burden of chronic health conditions. ObjectiveTo …

Overweight and obesity: a review of their relationship to metabolic syndrome, cardiovascular disease, and cancer in South America

LR Aballay, AR Eynard, MP Díaz, A Navarro… - Nutrition …, 2013 - academic.oup.com
Socioeconomic and demographic transformations are occurring very rapidly in some areas
of the world, especially in South America, and are accompanied by changes in lifestyle …

The impact of obesity and bariatric surgery on circulating and tissue biomarkers of endometrial cancer risk

ML MacKintosh, AE Derbyshire… - … journal of cancer, 2019 - Wiley Online Library
Obesity is the strongest risk factor for endometrial cancer (EC). To inform targeted screening
and prevention strategies, we assessed the impact of obesity and subsequent bariatric …

Metformin treatment exerts antiinvasive and antimetastatic effects in human endometrial carcinoma cells

BK Tan, R Adya, J Chen, H Lehnert… - The Journal of …, 2011 - academic.oup.com
Context: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women
associated with an increased risk of endometrial hyperplasia. We sought to study the effects …

Maternal obesity promotes a proinflammatory signature in rat uterus and blastocyst

K Shankar, Y Zhong, P Kang, F Lau… - …, 2011 - academic.oup.com
Maternal obesity at conception increases the risk of offspring obesity, thus propagating an
intergenerational vicious cycle. Male offspring born to obese dams are hyperresponsive to …

[PDF][PDF] Obesity‐driven endometrial cancer: is weight loss the answer?

ML Mackintosh, EJ Crosbie - … Journal of Obstetrics …, 2013 - research.manchester.ac.uk
Endometrial cancer is the fourth most common cancer affecting British women, behind
breast, lung and colon cancer. Over the past 20 years, the incidence of endometrial cancer …

Current perspectives of insulin resistance and polycystic ovary syndrome

JM Pauli, N Raja‐Khan, X Wu, RS Legro - Diabetic Medicine, 2011 - Wiley Online Library
Diabet. Med. 28, 1445–1454 (2011) Abstract Aims To review the relationship between
insulin resistance and polycystic ovary syndrome. Methods A literature review. Results …

Endometrium and steroids, a pathologic overview

F Plaza-Parrochia, C Romero, L Valladares, M Vega - Steroids, 2017 - Elsevier
Normal endometrial function requires of cell proliferation and differentiation; therefore,
disturbances in these processes could lead to pathological entities such as hyperplasia and …

[HTML][HTML] PCOS and obesity: insulin resistance might be a common etiology for the development of type I endometrial carcinoma

X Li, R Shao - American journal of cancer research, 2014 - ncbi.nlm.nih.gov
Endometrial cancer (EC) is the most common gynecological malignancy in women and is
the leading cause of cancer-related deaths worldwide. Estrogenic stimulation significantly …

Expression of hormone receptors, Bcl‑2, Cox‑2 and Ki67 in benign endometrial polyps and their association with obesity

A Pinheiro, A Antunes, L Andrade… - Molecular …, 2014 - spandidos-publications.com
The present study examined the immunoexpression of the estrogen receptor (ER), the
progesterone receptor (PR), B‑cell lymphoma 2 (Bcl‑2), cyclooxygenase‑2 (Cox‑2) and Ki67 …