The heme oxygenase (HO) enzyme system catabolizes heme to carbon monoxide (CO),
ferrous iron, and biliverdin-IXα (BV), which is reduced to bilirubin-IXα (BR) by biliverdin …

Heme oxygenase catalyzes the rate-limiting step in heme degradation in order to generate
biliverdin, carbon monoxide (CO), and iron. The inducible form of the enzyme, heme …

The heme oxygenase-1 (HO-1) enzyme system remains an attractive therapeutic target for
the treatment of inflammatory conditions. HO-1, a cellular stress protein, serves a vital …

The iron storage protein, ferritin, plays a key role in iron metabolism. Its ability to sequester
the element gives ferritin the dual functions of iron detoxification and iron reserve. The …

This review focuses on the role of oxidative processes in atherosclerosis and its resultant
cardiovascular events. There is now a consensus that atherosclerosis represents a state of …

The heme oxygenases, which consist of constitutive and inducible isozymes (HO-1, HO-2),
catalyze the rate-limiting step in the metabolic conversion of heme to the bile pigments (ie …

Lipid peroxidation is a well known example of oxidative damage in cell membranes,
lipoproteins, and other lipid-containing structures. Peroxidative modification of unsaturated …

▪ Abstract The heme oxygenase (HO) system consists of two forms identified to date: the
oxidative stress–inducible protein HO-1 (HSP32) and the constitutive isozyme HO-2. These …

Accumulating evidence suggests that oxidative stress plays a central role in the
pathogenesis of many pulmonary diseases including adult respiratory distress syndrome …

The cap'n'collar (CNC) bZIP transcription factor Nrf2 controls expression of genes for
antioxidant enzymes, metal-binding proteins, drug-metabolising enzymes, drug transporters …