Alzheimer's disease (AD) is a chronic neurodegenerative disease and the most frequent
cause of progressive dementia in senior adults. It is characterized by memory loss and …

Calcium (Ca2+) is a versatile secondary messenger involved in the regulation of a plethora
of different signaling pathways for cell maintenance. Specifically, intracellular Ca2+ …

Neural stem cells in the adult brain exist primarily in a quiescent state but are reactivated in
response to changing physiological conditions. How do stem cells sense and respond to …

Regulation of stem cells requires coordination of the cells that make up the stem cell niche.
Here, we describe a mechanism that allows communication between niche cells to …

Simple Summary Cell fate is ultimately determined by the precisely coordinated action of the
Ca2+-signaling machinery. During carcinogenesis, Ca2+ signaling is significantly …

Stem cell homeostasis requires coordinated fate decisions among stem cells that are often
widely distributed within a tissue at varying distances from their stem cell niche. This …

Sonogenetics is an emerging medical technology that uses acoustic waves to control cells
through sonosensitive mediators (SSMs) that are genetically encoded, thus remotely and …

Abstract Calcium ions (Ca2+) play crucial roles in almost every cellular process, making the
detection of changes in intracellular Ca2+ essential to understanding cell function. The …

Reactive oxygen species (ROS) are now recognized as important second messengers with
roles in many aspects of signaling during leukemogenesis. They serve as critical cell …

Abstract T-type Ca2+ channels (TTCC) have been identified as key regulators of cancer cell
cycle and survival. In vivo studies in glioblastoma (GBM) murine xenografts have shown that …