Aneuploidy in human cancer: new tools and perspectives
Chromosome copy number imbalances, otherwise known as aneuploidies, are a common
but poorly understood feature of cancer. Here, we describe recent advances in both …
but poorly understood feature of cancer. Here, we describe recent advances in both …
Oncogene-like addiction to aneuploidy in human cancers
Most cancers exhibit aneuploidy, but its functional significance in tumor development is
controversial. Here, we describe ReDACT (Restoring Disomy in Aneuploid cells using …
controversial. Here, we describe ReDACT (Restoring Disomy in Aneuploid cells using …
Chromosomal instability accelerates the evolution of resistance to anti-cancer therapies
Aneuploidy is a ubiquitous feature of human tumors, but the acquisition of aneuploidy
typically antagonizes cellular fitness. To investigate how aneuploidy could contribute to …
typically antagonizes cellular fitness. To investigate how aneuploidy could contribute to …
Micronuclei-based model system reveals functional consequences of chromothripsis in human cells
M Kneissig, K Keuper, MS de Pagter… - Elife, 2019 - elifesciences.org
Cancer cells often harbor chromosomes in abnormal numbers and with aberrant structure.
The consequences of these chromosomal aberrations are difficult to study in cancer, and …
The consequences of these chromosomal aberrations are difficult to study in cancer, and …
Single-chromosomal gains can function as metastasis suppressors and promoters in colon cancer
High levels of cancer aneuploidy are frequently associated with poor prognosis. To examine
the relationship between aneuploidy and cancer progression, we analyzed a series of …
the relationship between aneuploidy and cancer progression, we analyzed a series of …
Patient-derived triple-negative breast cancer organoids provide robust model systems that recapitulate tumor intrinsic characteristics
S Bhatia, M Kramer, S Russo, P Naik, G Arun, K Brophy… - Cancer research, 2022 - AACR
Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer with poor
patient outcomes, highlighting the unmet clinical need for targeted therapies and better …
patient outcomes, highlighting the unmet clinical need for targeted therapies and better …
iCopyDAV: Integrated platform for copy number variations—Detection, annotation and visualization
P Dharanipragada, S Vogeti, N Parekh - PLoS One, 2018 - journals.plos.org
Discovery of copy number variations (CNVs), a major category of structural variations, have
dramatically changed our understanding of differences between individuals and provide an …
dramatically changed our understanding of differences between individuals and provide an …
High resolution copy number inference in cancer using short-molecule nanopore sequencing
Genome copy number is an important source of genetic variation in health and disease. In
cancer, Copy Number Alterations (CNAs) can be inferred from short-read sequencing data …
cancer, Copy Number Alterations (CNAs) can be inferred from short-read sequencing data …
The human origin recognition complex is essential for pre-RC assembly, mitosis, and maintenance of nuclear structure
HC Chou, K Bhalla, OEL Demerdesh, O Klingbeil… - Elife, 2021 - elifesciences.org
The origin recognition complex (ORC) cooperates with CDC6, MCM2-7, and CDT1 to form
pre-RC complexes at origins of DNA replication. Here, using tiling-sgRNA CRISPR screens …
pre-RC complexes at origins of DNA replication. Here, using tiling-sgRNA CRISPR screens …
[HTML][HTML] Diagnostic yields of trio-WES accompanied by CNVseq for rare neurodevelopmental disorders
C Gao, X Wang, S Mei, XA Yang - Frontiers in genetics, 2019 - frontiersin.org
Objective This study is to investigate the diagnostic yield of the combination of trio whole
exome sequencing (Trio-WES) and copy number variation sequencing (CNVseq) for rare …
exome sequencing (Trio-WES) and copy number variation sequencing (CNVseq) for rare …