Angiogenesis, the formation of new blood vessels, is a complex and dynamic process
regulated by various pro-and anti-angiogenic molecules, which plays a crucial role in tumor …

The receptor tyrosine-kinase HER2 (also known as ErbB2) is a well-established therapeutic
target in patients with breast or gastric cancer selected on the basis of HER2 overexpression …

Simple Summary Gastric cancer (GC) is regarded as one of the most perilous malignancies
globally, with over one billion new cases and seven hundred and eighty-three thousand …

Fibroblast growth factor (FGF) signalling via FGF receptors (FGFR1–4) orchestrates fetal
development and contributes to tissue and whole-body homeostasis, but can also promote …

There are five fibroblast growth factor receptors (FGFRs), namely, FGFR1–FGFR5. When
FGFR binds to its ligand, namely, fibroblast growth factor (FGF), it dimerizes and …

Cancer is the leading cause of death worldwide; thus, it is necessary to find successful
strategies. Several growth factors, such as vascular endothelial growth factor (VEGF), basic …

Gastric cancer is a heterogeneous disease with diverse histological and genomic subtypes,
making it difficult to demonstrate treatment efficacy in clinical trials. However, recent efforts …

Abstract Claudin 18.2, a tight-junction molecule predominantly found in the nonmalignant
gastric epithelium, becomes accessible on the tumour cell surface during malignant …

Most protein-coding genes produce multiple protein isoforms; however, these isoforms are
commonly neglected in drug discovery. The expression of protein isoforms can be specific to …

According to the 2020 global cancer data released by the World Cancer Research Fund
(WCRF) International, gastric cancer (GC) is the fifth most common cancer worldwide, with …