Immunotherapy aims to activate the immune system to fight cancer in a very specific and
targeted manner. Despite the success of different immunotherapeutic strategies, in particular …

Disparity during the resolution of inflammation is closely related with the initiation and
progression of the tumorigenesis. The transformed cells, through continuously evolving …

Cancer development is a multistep process that may be induced by a variety of compounds.
Environmental substances, such as pesticides, have been associated with different human …

Biglycan, a small leucine rich proteoglycan (SLRP), is an important participant in bone
homeostasis and development as well as in bone pathology. In the present study biglycan …

Hormone-dependent cancers exhibit high morbidity and mortality. In spite of advances in
therapy, the treatment of hormone-dependent cancers remains an unmet health need. The …

Glioblastoma (GBM) is a stage IV astrocytoma that carries a dismal survival rate of≈ 10
months postdiagnosis and treatment. The highly invasive capacity of GBM and its ability to …

Background Despite immunotherapies having revolutionized the treatment of advanced
cutaneous melanoma, effective and durable responses were only reported in a few patients …

The extracellular matrix component biglycan (BGN) plays an essential role in various
physiological and pathophysiological processes. A deficient BGN expression associated …

Glioblastoma (GBM) is a common malignant tumor of the brain. Members of the
carbohydrate sulfotransferase (CHST) family are deregulated in various cancer types …

Carbohydrate sulfotransferase 4 (CHST4) plays an important role in lymphocyte homing and
is abnormally expressed in several cancer types; however, its precise function in tumor …