Spermatogenesis is an extraordinary complex process. The differentiation of spermatogonia
into spermatozoa requires the participation of several cell types, hormones, paracrine …

The blood-testis barrier (BTB) is one of the tightest blood-tissue barriers in the mammalian
body. It divides the seminiferous epithelium into the basal and the apical (adluminal) …

Transporters influence the disposition of chemicals within the body by participating in
absorption, distribution, and elimination. Transporters of the solute carrier family (SLC) …

Since cloning of the ATP-binding cassette (ABC) family member breast cancer resistance
protein (BCRP/ABCG2) and its characterization as a multidrug resistance efflux transporter …

ABC (ATP-binding cassette) transporters represent one of the largest and most diverse
superfamily of proteins in living species, playing an important role in many biological …

ABCG2, or breast cancer resistance protein (BCRP), is an ABC transporter that has been the
subject of intense study since its discovery a decade ago. With high normal tissue …

Multidrug resistance (MDR) is a pathophysiological phenomenon employed by cancer cells
which limits the prolonged and effective use of chemotherapeutic agents. MDR is primarily …

Quercetin is a dietary polyphenolic compound with potentially beneficial effects on health.
Claims that quercetin has biological effects are based mainly on in vitro studies with …

The adenosine triphosphate (ATP)-binding cassette efflux transporter G2 (ABCG2) was
originally discovered in a multidrug-resistant breast cancer cell line. Studies in the past have …

ABCC2 is a member of the multidrug resistance protein subfamily localized exclusively to
the apical membrane domain of polarized cells, such as hepatocytes, renal proximal tubule …