Mutations in leucine-rich repeat kinase 2 (LRRK2) cause autosomal dominant familial
Parkinson's disease (PD), with pathogenic mutations enhancing LRRK2 kinase activity …

Lysosomes are acidic and degradative organelles that receive and digest a plethora of
molecular and particulate cargo delivered by endocytosis, autophagy, and phagocytosis …

A growing list of Alzheimer's disease (AD) genetic risk factors is being identified, but the
contribution of each variant to disease mechanism remains largely unknown. We have …

The molecular events that determine the recycling versus degradation fates of internalized
membrane proteins remain poorly understood. Two of the three members of the SNX-FERM …

Parkinson´ s disease (PD) is a progressive neurodegenerative disorder characterized by
both motor and non-motor symptoms. Aggravation of symptoms is mirrored by accumulation …

How do neurons adapt their endolysosomal system to address the particular challenge of
membrane transport across their elaborate cellular landscape and to maintain proteostasis …

Alternative DNA conformations, termed non-B DNA structures, can affect transcription, but
the underlying mechanisms and their functional impact have not been systematically …

Protein homeostasis is maintained by removing misfolded, damaged, or excess proteins and
damaged organelles from the cell by three major pathways; the ubiquitin-proteasome …

Aberrations in membrane trafficking pathways have profound effects in cellular dynamics of
cellular sorting processes and can drive severe physiological outcomes. Sorting nexin 27 …

After binding to its cell surface receptor angiotensin converting enzyme 2 (ACE2), severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters the host cell through directly …