Pharmacological properties of chalcones: a review of preclinical including molecular mechanisms and clinical evidence

B Salehi, C Quispe, I Chamkhi, N El Omari… - Frontiers in …, 2021 - frontiersin.org
Chalcones are among the leading bioactive flavonoids with a therapeutic potential
implicated to an array of bioactivities investigated by a series of preclinical and clinical …

Pharmacotherapeutics applications and chemistry of chalcone derivatives

JS Dhaliwal, S Moshawih, KW Goh, MJ Loy… - Molecules, 2022 - mdpi.com
Chalcones have been well examined in the extant literature and demonstrated antibacterial,
antifungal, anti-inflammatory, and anticancer properties. A detailed evaluation of the …

Chalcones: Synthetic chemistry follows where nature leads

HA Jasim, L Nahar, MA Jasim, SA Moore, KJ Ritchie… - Biomolecules, 2021 - mdpi.com
Chalcones belong to the flavonoid class of phenolic compounds. They form one of the
largest groups of bioactive natural products. The potential anticancer, anti-inflammatory …

Exploring pharmacological significance of chalcone scaffold: a review

NK Sahu, SS Balbhadra… - Current medicinal …, 2012 - ingentaconnect.com
Chalcones (1, 3-diaryl-2-propen-1-ones) and their heterocyclic analogues, belong to the
flavonoid family, which possess a number of interesting biological properties such as …

Plant growth-promoting effects of diazotrophs in the rhizosphere

S Dobbelaere, J Vanderleyden… - Critical reviews in plant …, 2003 - Taylor & Francis
Because of their ability to transform atmospheric N2 into ammonia that can be used by the
plant, researchers were originally very optimistic about the potential of associative …

A review of anti-infective and anti-inflammatory chalcones

Z Nowakowska - European journal of medicinal chemistry, 2007 - Elsevier
Chalcones, considered as the precursors of flavonoids and isoflavonoids, are abundant in
edible plants, and have also been shown to display a diverse array of pharmacological …

[HTML][HTML] Bis-chalcones: A review of synthetic methodologies and anti-inflammatory effects

R Pereira, AMS Silva, D Ribeiro, VLM Silva… - European Journal of …, 2023 - Elsevier
Chalcones are bioactive molecules of natural and synthetic sources, whose
physicochemical properties, reactivity, and biological activities are well-known among the …

Chalcone scaffolds as anti-infective agents: Structural and molecular target perspectives

DK Mahapatra, SK Bharti, V Asati - European journal of medicinal chemistry, 2015 - Elsevier
In recent years, widespread outbreak of numerous infectious diseases across the globe has
created havoc among the population. Particularly, the inhabitants of tropical and sub-tropical …

The role of chalcones in suppression of NF-κB-mediated inflammation and cancer

VR Yadav, S Prasad, B Sung, BB Aggarwal - International …, 2011 - Elsevier
Although consumption of fruits, vegetables, spices, cereals and pulses has been associated
with lower incidence of cancer and other chronic diseases, how these dietary agents and …

Antifungal activity of chalcones: A mechanistic study using various yeast strains

KL Lahtchev, DI Batovska, P St P, VM Ubiyvovk… - European journal of …, 2008 - Elsevier
We reported the synthesis, antifungal evaluation and study on substituent effects of 21
chalcones. A lot of genetically defined strains belonging to different yeast genera and …