Cyanobacterial toxins in freshwater and food: important sources of exposure to humans

J Lee, S Lee, X Jiang - Annual review of food science and …, 2017 - annualreviews.org
A recent ecological study demonstrated a significant association between an increased risk
of nonalcoholic liver disease mortality and freshwater cyanobacterial blooms. Moreover …

Extrapolation of phenolic compounds as multi-target agents against cancer and inflammation

N Kumar, S Gupta, T Chand Yadav… - Journal of …, 2019 - Taylor & Francis
Natural products acquire massive structural and chemical diversity, which cannot be
coordinated by any synthetic libraries for small molecules and they are continuing to inspire …

Structural, thermal and quantum chemical studies of p-coumaric and caffeic acids

N Kumar, V Pruthi, N Goel - Journal of Molecular Structure, 2015 - Elsevier
Two hydroxycinnamic acids viz., p-coumaric, and caffeic acids have been extracted and
purified from Parthenium hysterophorus, subsequently characterized by elemental analysis …

Exploration of interaction mechanism of tyrosol as a potent anti-inflammatory agent

TC Yadav, N Kumar, U Raj, N Goel… - Journal of …, 2020 - Taylor & Francis
Drug discovery for a vigorous and feasible lead candidate is a challenging scientific mission
as it requires expertise, experience, and huge investment. Natural products and their …

Quantum chemical, ADMET and molecular docking studies of ferulic acid amide derivatives with a novel anticancer drug target

N Kumar, N Goel, T Chand Yadav, V Pruthi - Medicinal Chemistry …, 2017 - Springer
Cancer is among the major health problems and leading cause of deaths worldwide. As per
the World Health Organization report, the number of cancer patients will increase up to≥ …

Ferulic acid amide derivatives as anticancer and antioxidant agents: synthesis, thermal, biological and computational studies

N Kumar, S Kumar, S Abbat, K Nikhil… - Medicinal Chemistry …, 2016 - Springer
The design and microwave-assisted synthesis of four series (IIIa–IIIo, Va–Vg, VIIa–VIIg and
IXa–IXe) of mono and bis-amide derivatives of ferulic acid have been achieved under …

Application of computational techniques to unravel structure-function relationship and their role in therapeutic development

TC Yadav, AK Srivastava, A Dey… - Current Topics in …, 2018 - ingentaconnect.com
Application of computational tools and techniques has emerged as an invincible instrument
to unravel the structure-function relationship and offered better mechanistic insights in the …

Extrapolation of hydroxytyrosol and its analogues as potential anti-inflammatory agents

N Kumar, B Gorai, S Gupta, Shiva… - Journal of Biomolecular …, 2021 - Taylor & Francis
Discovery of potential lead molecule is a challenging, and complex process which require
lots of money, patience, and manpower. Human beings are using natural products …

Synthetic Haptens and Monoclonal Antibodies to the Cyanotoxin Anatoxin‐a

G Quiñones‐Reyes, C Agulló… - Angewandte Chemie …, 2019 - Wiley Online Library
Early warning systems for monitoring toxic events may benefit from the availability of
monoclonal antibodies enabling the sensitive and specific detection of anatoxin‐a, a …

Interaction mechanism of pepsin with a natural inhibitor gastrodin studied by spectroscopic methods and molecular docking

J Wang, C Chan, F Huang, J Xie, H Xu, K Ho… - Medicinal Chemistry …, 2017 - Springer
The interaction of gastrodin with pepsin has been investigated by enzyme activity assay,
fluorescence, UV–Visible, circular dichroism spectra, and molecular docking. The pepsin …