Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number
of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating …

Novel and effective antiseizure medications are needed to treat refractory and rare forms of
epilepsy. Cannabinoids, which are obtained from the cannabis plant, have a long history of …

Status epilepticus (SE), a medical emergency that is typically terminated through
antiepileptic drug treatment, leads to hippocampus dysfunction typified by …

Acute seizures after a severe brain insult can often lead to epilepsy and cognitive
impairment. Aberrant hippocampal neurogenesis follows the insult but the role of adult …

The hippocampus is the most common seizure focus in people. In the hippocampus,
aberrant neurogenesis plays a critical role in the initiation and progression of epilepsy in …

Adult hippocampal neurogenesis is believed to maintain a range of cognitive functions,
many of which decline with age. We recently reported that radial neural stem cells (rNSCs) …

Seizure activity in the hippocampal region strongly affects stem cell-associated plasticity in
the adult dentate gyrus. Here, we describe how seizures in rodent models of mesial …

New neurons are generated in the adult hippocampus of many species including rodents,
monkeys, and humans. Conditions associated with major depression, such as social stress …

It is now well established that the mammalian brain has the capacity to produce new
neurons into adulthood. One such region that provides the proper milieu to sustain …

Cannabis-derived cannabinoids have neuroactive properties. Recently, there has been
emerging interest in the use of cannabidiol (CBD)-enriched products for treatment of drug …