Recent studies across multiple tumour types are starting to reveal a recurrent regulatory
architecture in which genomic alterations cluster upstream of functional master regulator …

Current efforts in precision oncology largely focus on the benefit of genomics-guided
therapy. Yet, advances in sequencing techniques provide an unprecedented view of the …

Identifying the multiple dysregulated oncoproteins that contribute to tumorigenesis in a given
patient is crucial for developing personalized treatment plans. However, accurate inference …

Systematic perturbation of cells followed by comprehensive measurements of molecular and
phenotypic responses provides informative data resources for constructing computational …

Long noncoding RNAs (lncRNAs) are commonly dysregulated in tumors, but only a handful
are known to play pathophysiological roles in cancer. We inferred lncRNAs that dysregulate …

By analyzing gene expression data in glioblastoma in combination with matched microRNA
profiles, we have uncovered a posttranscriptional regulation layer of surprising magnitude …

Purpose Rearrangement of MYC occurs in a proportion of diffuse large B-cell lymphomas
(DLBCL), where they may be associated with an adverse clinical outcome. The aim of this …

MicroRNAs (miRNAs) show differential expression across breast cancer subtypes, and have
both oncogenic and tumour-suppressive roles,,,,,. Here we report the miRNA expression …

Despite considerable efforts, the mechanisms linking genomic alterations to the
transcriptional identity of cancer cells remain elusive. Integrative genomic analysis, using a …

The pathways regulating formation of the germinal center (GC) dark zone (DZ) and light
zone (LZ) are unknown. In this study we show that FOXO1 transcription factor expression …