Heart failure with preserved ejection fraction (HFpEF) affects half of all patients with heart
failure worldwide, is increasing in prevalence, confers substantial morbidity and mortality …

Right ventricular fibrosis is a stress response, predominantly mediated by cardiac
fibroblasts. This cell population is sensitive to increased levels of pro-inflammatory …

Ischemic heart disease (IHD) and dilated cardiomyopathy (DCM) are the two most common
etiologies of heart failure (HF). Both forms share common characteristics including ventricle …

Background: Right ventricular (RV) dysfunction is a significant prognostic determinant of
morbidity and mortality in pulmonary arterial hypertension (PAH). Despite the importance of …

Cardiovascular diseases are the leading cause of death worldwide, with heart failure being
a complex condition that affects millions of individuals. Single-nucleus RNA sequencing has …

Background: Pulmonary hypertension (PH) is a pulmonary vascular disease characterized
by elevated pulmonary vascular pressure. Long-term PH, irrespective of its etiology, leads to …

Secreted extracellular matrix components which regulate craniofacial development could be
reactivated and play roles in adult wound healing. We report a patient with a loss-of-function …

The right ventricle has long been perceived as the “low pressure bystander” of the left
ventricle. Although the structure consists of, at first glance, the same cardiomyocytes as the …

Despite the availability of several effective and promising treatment methods, heart failure
(HF) remains a significant public health concern that requires advanced therapeutic …

Background Left-sided heart failure (HF) is documented as a key prognostic factor in HF.
However, the relative molecular mechanisms underlying left-sided HF is unknown. The …