Marine natural products

AR Carroll, BR Copp, RA Davis, RA Keyzers… - Natural product …, 2021 - pubs.rsc.org
This review covers the literature published in 2019 for marine natural products (MNPs), with
719 citations (701 for the period January to December 2019) referring to compounds …

Single-atom logic for heterocycle editing

J Jurczyk, J Woo, SF Kim, BD Dherange, R Sarpong… - Nature …, 2022 - nature.com
Medicinal chemistry continues to be impacted by new synthetic methods. Particularly sought
after, especially at the drug discovery stage, is the ability to enact the desired chemical …

Recent progress in the total synthesis of pyrrole-containing natural products (2011–2020)

N Singh, S Singh, S Kohli, A Singh, H Asiki… - Organic Chemistry …, 2021 - pubs.rsc.org
Natural products have long served as a rich resource for drug discovery in the treatment of
illnesses and chronic diseases. Among many families exhibiting fascinating structural …

Marine pyrrole alkaloids

K Seipp, L Geske, T Opatz - Marine Drugs, 2021 - mdpi.com
Nitrogen heterocycles are essential parts of the chemical machinery of life and often reveal
intriguing structures. They are not only widespread in terrestrial habitats but can also …

Recent Advances in Synthetic Methods by Photocatalytic Single-Electron Transfer Chemistry of Pyridine N-Oxides

V Satheesh, Y Deng - The Journal of organic chemistry, 2024 - ACS Publications
By adoption of the enabling technology of modern photoredox catalysis and photochemistry,
the generation of reactive and versatile pyridine N-oxy radicals can be facilely achieved from …

Photochemical dearomative skeletal modifications of heteroaromatics

P Ji, K Duan, M Li, Z Wang, X Meng, Y Zhang… - Chemical Society …, 2024 - pubs.rsc.org
Dearomatization has emerged as a powerful tool for rapid construction of 3D molecular
architectures from simple, abundant, and planar (hetero) arenes. The field has evolved …

Photochemical Skeletal Editing of Pyridines to Bicyclic Pyrazolines and Pyrazoles

J Luo, Q Zhou, Z Xu, KN Houk… - Journal of the American …, 2024 - ACS Publications
We present an efficient one-pot photochemical skeletal editing protocol for the
transformation of pyridines into diverse bicyclic pyrazolines and pyrazoles under mild …

Total synthesis and complete configurational assignment of amphirionin-2

S Kato, D Mizukami, T Sugai, M Tsuda, H Fuwa - Chemical Science, 2021 - pubs.rsc.org
Amphirionin-2 is a linear polyketide metabolite that exhibits potent and selective cytotoxic
activity against certain human cancer cell lines. We disclose herein the first total synthesis of …

Photoinduced Pyridine N‐oxides Catalyzed Carbon Radical Generation from Alkylboronic Acids

C Ascenzi‐Pettenuzzo, J Nganda, Y Deng - ChemCatChem, 2023 - Wiley Online Library
Herein we report a protocol for the generation of alkyl carbon radicals from alkylboronic
acids wherein photoexcited 4‐nitropyridine N‐oxide biradical features a catalyst to promote …

Photorearrangement of [8]-2,6-Pyridinophane N-Oxide

EE Hurlow, JB Lin, MJ Dweck, S Nuryyeva… - Journal of the …, 2020 - ACS Publications
Reaction pathways operative when pyridinophane N-oxides are photoirradiated have been
studied using time course analyses and careful isolation of photolabile intermediates with …