Major recent advances and previous data have led to a plausible model of how key proteins
mediate neurotransmitter release. In this model, the soluble N-ethylmaleimide-sensitive …

Abstract α-Synuclein is a neuronal protein that is enriched in presynaptic terminals. Under
physiological conditions, it binds to synaptic vesicle membranes and functions in …

Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) are a
family of small conserved eukaryotic proteins that mediate membrane fusion between …

The protein α‐synuclein has a central role in the pathogenesis of Parkinson's disease (PD).
In this review, we discuss recent results concerning its primary function, which appears to be …

Sec1/Munc18-family (SM) proteins are required for SNARE-mediated membrane fusion, but
their mechanism (s) of action remain controversial. Using single-molecule force …

Intracellular vesicle trafficking is the fundamental process to maintain the homeostasis of
membrane-enclosed organelles in eukaryotic cells. These organelles transport cargo from …

Synaptic vesicle (SV) exocytosis is mediated by SNARE proteins. Reconstituted SNAREs
are constitutively active, so a major focus has been to identify fusion clamps that regulate …

Abstract Synaptobrevin‐2 (Syb2) is a soluble N‐ethylmaleimide‐sensitive factor attachment
protein receptor (SNARE) that is essential for neurotransmitter release. It is the most …

Exocytosis is a fundamental membrane fusion process by which the soluble or membrane-
associated cargoes of a secretory vesicle are delivered to the extracellular milieu or the cell …

The revolution in genetic technology has ushered in a new age for our understanding of the
underlying causes of neurodevelopmental, neuromuscular and neurodegenerative …