Rho-associated kinases ROCK1 and ROCK2 are key regulators of actin cytoskeleton
dynamics downstream of Rho GTPases that participate in the control of important …

Abstract The small Rho GTPase family of proteins, encompassing the three major G-protein
classes Rho, Rac and cell division control protein 42, are key mitogenic signaling molecules …

Rho kinase (ROCK) is a major downstream effector of the small GTPase RhoA. ROCK
family, consisting of ROCK1 and ROCK2, plays central roles in the organization of actin …

Next to changes in cytosolic [Ca2+], members of the Rho subfamily of small GTPases, in
particular Rho and its effector Rho kinase, also known as ROK or ROCK, emerged as key …

Rho kinase (ROCK) belongs to the AGC (PKA/PKG/PKC) family of serine/threonine kinases
and is a major downstream effector of the small GTPase RhoA. ROCK plays central roles in …

RhoA/Rho-kinase pathway plays an important role in many pathological conditions. RhoA
participates in the regulation of smooth muscle tone and activates many downstream …

Arterial hypertension is a common health problem that affects 25% of the adult population in
industrialized societies, and is a major risk factor for myocardial infarction and stroke …

Hypertension is a major public health problem in the developing as well as in developed
countries due to its high prevalence and its association with coronary heart disease, renal …

The emerging critical implications of Rho/Rho-kinase (ROCK) signaling in
neurodegenerative diseases, glaucoma, renoprotection, diabetes and cancer have sparked …

Small G proteins exist in eukaryotes from yeast to human and constitute the Ras superfamily
comprising more than 100 members. This superfamily is structurally classified into five …