Clostridioides difficile infection: history, epidemiology, risk factors, prevention, clinical manifestations, treatment, and future options

S Di Bella, G Sanson, J Monticelli… - Clinical Microbiology …, 2024 - Am Soc Microbiol
Clostridioides difficile infection (CDI) is one of the major issues in nosocomial infections.
This bacterium is constantly evolving and poses complex challenges for clinicians, often …

A novel synbiotic alleviates autoimmune hepatitis by modulating the gut microbiota-liver axis and inhibiting the hepatic TLR4/NF-κB/NLRP3 signaling pathway

Y Kang, X Kuang, H Yan, P Ren, X Yang, H Liu, Q Liu… - Msystems, 2023 - Am Soc Microbiol
Autoimmune hepatitis (AIH) is a liver disease characterized by chronic liver inflammation.
The intestinal barrier and microbiome play critical roles in AIH progression. AIH treatment …

Dietary sodium butyrate supplementation attenuates intestinal inflammatory response and improves gut microbiota composition in largemouth bass (Micropterus …

W Chen, K Chang, J Chen, X Zhao, S Gao - Fish Physiology and …, 2021 - Springer
The study aimed to investigate the effects of dietary sodium butyrate (NaBT)
supplementation on the gut health of largemouth bass (Micropterus salmoides) fed with a …

The impact of pH on Clostridioides difficile sporulation and physiology

D Wetzel, SM McBride - Applied and environmental microbiology, 2020 - Am Soc Microbiol
Clostridioides difficile is a pathogenic bacterium that infects the human colon to cause
diarrheal disease. Growth of the bacterium is known to be dependent on certain bile acids …

Microbiota-derived short-chain fatty acids promote LAMTOR2-mediated immune responses in macrophages

T Wu, H Li, C Su, F Xu, G Yang, K Sun, M Xu, N Lv… - Msystems, 2020 - Am Soc Microbiol
Klebsiella pneumoniae is a common cause of human-pneumonia-derived sepsis with high
morbidity and mortality. The microbiota promotes and maintains host immune homeostasis …

Butyrate differentiates permissiveness to Clostridioides difficile infection and influences growth of diverse C. difficile isolates

DA Pensinger, AT Fisher, HA Dobrila… - Infection and …, 2023 - Am Soc Microbiol
ABSTRACT A disrupted “dysbiotic” gut microbiome engenders susceptibility to the diarrheal
pathogen Clostridioides difficile by impacting the metabolic milieu of the gut. Diet, in …

A High-Fat/High-Protein, Atkins-Type Diet Exacerbates Clostridioides (Clostridium) difficile Infection in Mice, whereas a High-Carbohydrate Diet Protects

CC Mefferd, SS Bhute, JR Phan, JV Villarama, DM Do… - Msystems, 2020 - Am Soc Microbiol
Clostridioides difficile (formerly Clostridium difficile) infection (CDI) can result from the
disruption of the resident gut microbiota. Western diets and popular weight-loss diets drive …

Hypoxia-inducible factor-driven glycolytic adaptations in host-microbe interactions

E DeMichele, AG Buret, CT Taylor - Pflügers Archiv-European Journal of …, 2024 - Springer
Mammalian cells utilize glucose as a primary carbon source to produce energy for most
cellular functions. However, the bioenergetic homeostasis of cells can be perturbed by …

Exogenous butyrate inhibits butyrogenic metabolism and alters virulence phenotypes in Clostridioides difficile

DA Pensinger, HA Dobrila, DM Stevenson… - Mbio, 2024 - Am Soc Microbiol
The gut microbiome engenders colonization resistance against the diarrheal pathogen
Clostridioides difficile, but the molecular basis of this colonization resistance is incompletely …

Butyrate ameliorates intraocular bacterial infection by promoting autophagy and attenuating the inflammatory response

S Singh, PK Singh, A Kumar - Infection and Immunity, 2023 - Am Soc Microbiol
Despite an important link between the gut and ocular health, the role of the gut-eye axis
remains elusive in ocular infections. In this study, we investigated the role of butyrate, a gut …