Sirtuins are nicotinamide adenine dinucleotide (NAD+)-dependent deacylases that have
traditionally been linked with calorie restriction and aging in mammals. These proteins also …

Neurodegenerative diseases (NDs) are a wide class of disorders of the central nervous
system (CNS) with unknown etiology. Several factors were hypothesized to be involved in …

Sirtuin enzymes are a family of highly conserved protein deacetylases that depend on
nicotinamide adenine dinucleotide (NAD+) for their activity. There are seven sirtuins in …

Throughout the genome, unstable tandem nucleotide repeats can expand to cause a variety
of neurologic disorders. Expansion of a CAG triplet repeat within a coding exon gives rise to …

Spinal and bulbar muscular atrophy (SBMA), also known as Kennedy's disease, is a rare, X-
linked hereditary lower motor neuron disease, characterized by progressive muscular …

Spinal and bulbar muscular atrophy (SBMA) is an X-linked, adult-onset neuromuscular
condition caused by an abnormal polyglutamine (polyQ) tract expansion in androgen …

The polyglutamine (polyQ) diseases, such as Huntington's disease and several types of
spinocerebellar ataxias, are a group of inherited neurodegenerative diseases that are …

Spinal and bulbar muscular atrophy (SBMA) is a late-onset motor neuron disease
characterized by slowly progressive muscle weakness and atrophy. During the last two …

Amyotrophic Lateral Sclerosis and Other Motor Neuron Disease... : CONTINUUM: Lifelong
Learning in Neurology Account Register Activate Subscription Help Subscribe American …

Objectives: To characterize the clinical and genetic features of spinal bulbar muscular
atrophy (SBMA), a rare neurodegenerative disorder caused by the expansion of a CAG …